A synthetic peptide for use as a blocking control in assays to test for specificity of ACVR1 antibody, Alternative Names: ACVR1 control peptide, ACVR1 antibody Blocking Peptide, Anti-ACVR1 Blocking Peptide, Activin A Receptor Type I Blocking Peptide, ACTRI Blocking Peptide, ACVRLK2 Blocking Peptide, ALK2 Blocking Peptide, FOP Blocking Peptide, SKR1 Blocking Peptide
Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.