phosphorylated Adaptor For RNA Export (PHAX) (Middle Region) Peptide
PHAX
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all PHAX products
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- IMNGSRRRTP GGVFLNLLKN TPSISEEQIK DIFYIENQKE YENKKAARKR
- 产品特性
- This is a synthetic peptide designed for use in combination with anti- PHAX Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
- 别名
- RNUXA Peptide, 2810055C14Rik Peptide, 4933427L19Rik Peptide, AU018701 Peptide, AU018854 Peptide, D18Ertd65e Peptide, Rnuxa Peptide, p55 Peptide, phosphorylated adaptor for RNA export Peptide, PHAX Peptide, Phax Peptide
- 背景
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A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
Alias Symbols: RNUXA
Protein Size: 394 - 基因ID
- 51808
- NCBI登录号
- NM_032177, NP_115553
- UniProt
- Q9H814
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