KH Domain Containing, RNA Binding, Signal Transduction Associated 2 (KHDRBS2) (Middle Region) Peptide
KHDRBS2
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all KHDRBS2 products
- KHDRBS2 (KH Domain Containing, RNA Binding, Signal Transduction Associated 2 (KHDRBS2))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- HEAYEEYGYD DGYGGEYDDQ TYETYDNSYA TQTQSVPEYY DYGHGVSEDA
- 产品特性
- This is a synthetic peptide designed for use in combination with anti- KHDRBS2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- KHDRBS2 (KH Domain Containing, RNA Binding, Signal Transduction Associated 2 (KHDRBS2))
- 别名
- slm1 Peptide, slm-1 Peptide, MGC145973 Peptide, ba535f17.1 Peptide, zgc:153588 Peptide, SLM-1 Peptide, SLM1 Peptide, bA535F17.1 Peptide, 6330586C16Rik Peptide, Slim1 Peptide, Slm1 Peptide, KH RNA binding domain containing, signal transduction associated 2 Peptide, KH domain containing, RNA binding, signal transduction associated 2 Peptide, KHDRBS2 Peptide, khdrbs2 Peptide, Khdrbs2 Peptide
- 背景
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RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.
Alias Symbols: SLM1, SLM-1
Protein Size: 349 - 基因ID
- 202559
- NCBI登录号
- NM_152688, NP_689901
- UniProt
- Q5VWX1
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