phosphorylase, Glycogen, Liver (PYGL) (Middle Region) Peptide
PYGL
适用: 人
宿主: 合成
WB, BP
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- 抗原 See all PYGL products
- PYGL (phosphorylase, Glycogen, Liver (PYGL))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Western Blotting (WB), Blocking Peptide (BP)
- 序列
- IVKTKVFKDF SELEPDKFQN KTNGITPRRW LLLCNPGLAE LIAEKIGEDY
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PYGL Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PYGL (phosphorylase, Glycogen, Liver (PYGL))
- 别名
- zgc:66314 Peptide, GSD6 Peptide, glycogen phosphorylase L Peptide, phosphorylase, glycogen, liver Peptide, phosphorylase, glycogen, liver S homeolog Peptide, liver glycogen phosphorylase Peptide, PYGL Peptide, pygl Peptide, pygl.S Peptide, Pygl Peptide
- 背景
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This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: GSD6
Protein Size: 813 - 基因ID
- 5836
- NCBI登录号
- NM_001163940, NP_001157412
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