Protein Kinase N2 (PKN2) (C-Term) Peptide
PKN2
适用: 人, 小鼠
宿主: 合成
BP, WB
-
- 抗原 See all PKN2 products
- PKN2 (Protein Kinase N2 (PKN2))
- 蛋白结构域
- C-Term
- 宿主
- 人, 小鼠
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-Pkn2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- PKN2 (Protein Kinase N2 (PKN2))
- 别名
- PAK2 Peptide, PRK2 Peptide, PRKCL2 Peptide, PRO2042 Peptide, Pak-2 Peptide, 6030436C20Rik Peptide, AI507382 Peptide, Prkcl2 Peptide, Stk7 Peptide, pak2 Peptide, prk2 Peptide, pak-2 Peptide, pro2042 Peptide, PKN2 Peptide, si:ch211-83f14.1 Peptide, wu:fa97c07 Peptide, protein kinase N2 Peptide, protein kinase N2 L homeolog Peptide, PKN2 Peptide, Pkn2 Peptide, pkn2.L Peptide, pkn2 Peptide
- 背景
-
Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).
Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7
Protein Size: 983 - 分子量
- 111 kDa
- 基因ID
- 109333
- NCBI登录号
- NM_178654, NP_848769
- UniProt
- Q8BWW9
-
You are here:
