Kelch-Like 12 (Drosophila) (KLHL12) (N-Term) Peptide
KLHL12
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all KLHL12 products
- KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- EKGKPYVDIQ GLTASTMEIL LDFVYTETVH VTVENVQELL PAACLLQLKG
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-KLHL12 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))
- 别名
- zgc:92570 Peptide, wu:fi60g03 Peptide, C3ip1 Peptide, C3IP1 Peptide, DKIR Peptide, hDKIR Peptide, Ski2 like RNA helicase Peptide, kelch like family member 12 L homeolog Peptide, kelch like family member 12 Peptide, kelch-like family member 12 Peptide, kelch-like 12 Peptide, SKIV2L Peptide, klhl12.L Peptide, KLHL12 Peptide, klhl12 Peptide, Klhl12 Peptide
- 背景
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KLHL12 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
Alias Symbols: C3IP1, DKIR, hDKIR
Protein Size: 568 - 分子量
- 63 kDa
- 基因ID
- 59349
- NCBI登录号
- NM_021633, NP_067646
- UniProt
- Q53G59
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