Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N) (N-Term) Peptide
PCSK1N
适用: 人, 大鼠
宿主: 合成
BP, WB
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- 抗原 See all PCSK1N products
- PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))
- 蛋白结构域
- N-Term
- 宿主
- 人, 大鼠
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- STPLRLRRAV PRGEAAGAVQ ELARALAHLL EAERQERARA EAQEAEDQQA
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-Pcsk1n Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))
- 别名
- PROSAAS Peptide, SAAS Peptide, Saas Peptide, AI848336 Peptide, KEP Peptide, PEN Peptide, PEN19 Peptide, PEN20 Peptide, Pan3 Peptide, SAASCT Peptide, bLEN Peptide, lLEN Peptide, proSAAS Peptide, proprotein convertase subtilisin/kexin type 1 inhibitor Peptide, PCSK1N Peptide, Pcsk1n Peptide
- 背景
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Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Alias Symbols: Saas
Protein Size: 260 - 分子量
- 28 kDa
- 基因ID
- 246333
- NCBI登录号
- NM_019279, NP_062152
- UniProt
- Q9QXU9
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