SARS-Coronavirus Spike Protein (SARS-CoV S) (Intermediate Domain 2) Peptide
SARS-CoV S
适用: SARS Coronavirus (SARS-CoV)
BP
Sodium azide
产品编号 ABIN1382168
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for SARS-Coronavirus Spike Protein (SARS-CoV S) (Intermediate Domain 2) Peptide (ABIN1382168)
抗原
SARS-CoV Spike (SARS-CoV S)
(SARS-Coronavirus Spike Protein (SARS-CoV S))
宿主
SARS Coronavirus (SARS-CoV)
应用范围
Blocking Peptide (BP)
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蛋白结构域
- Intermediate Domain 2
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产品特性
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17 amino acids near the center of SARS Spike protein.
Virus
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应用备注
- SARS Spike peptide is used for blocking the activity of the SARS Spike.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 200 μg/mL
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缓冲液
- PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1 % bovine serum albumin and 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- SARS-CoV Spike (SARS-CoV S) (SARS-Coronavirus Spike Protein (SARS-CoV S))
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物质类
- Viral Protein
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背景
- Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak. The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection. The spike protein is the major target for neutralizing antibodies and vaccine development. The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19. The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein .
抗原
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