PDE8A 抗体
(phosphodiesterase 8A (PDE8A))
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
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Latest Publications for our PDE8A 抗体
: "Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa." in: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 147-156, (2017) (PubMed).: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).
: "Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain." in: Cellular signalling, Vol. 26, Issue 2, pp. 383-97, (2014) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "Distribution of PDE8A in the nervous system of the Sprague-Dawley rat." in: Journal of chemical neuroanatomy, Vol. 42, Issue 3, pp. 184-91, (2012) (PubMed).
: "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages." in: Virology, Vol. 420, Issue 1, pp. 32-42, (2011) (PubMed).
: "Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 51, pp. 17634-9, (2004) (PubMed).
: "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans." in: Cellular signalling, Vol. 15, Issue 6, pp. 565-74, (2003) (PubMed).
: "Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages." in: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10175-81, (2000) (PubMed).
: "An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo." in: The Journal of biological chemistry, Vol. 270, Issue 35, pp. 20832-40, (1995) (PubMed).
Aliases for PDE8A 抗体
phosphodiesterase 8A (PDE8A) 抗体phosphodiesterase 8A (Pde8a) 抗体
phosphodiesterase 8A (pde8a) 抗体
AI551852 抗体
HsT19550 抗体
Pde8 抗体
PDE8A 抗体
Pde8a 抗体
RNPDE8A 抗体
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