PDE8A 产品
(phosphodiesterase 8A (PDE8A))
Categories
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
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Featured PDE8A Categories
Recommended PDE8A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN518727
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
- (2)
Cat. No.
ABIN542843
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7155164
Quantity
100 μL
Datasheet
Datasheet
Recommended PDE8A ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6232261
Quantity
96 tests
Datasheet
Datasheet
Recommended PDE8A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314488
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314490
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3094410
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PDE8A Products
: "Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa." in: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 147-156, (2017) (PubMed).: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).
: "Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain." in: Cellular signalling, Vol. 26, Issue 2, pp. 383-97, (2014) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "Distribution of PDE8A in the nervous system of the Sprague-Dawley rat." in: Journal of chemical neuroanatomy, Vol. 42, Issue 3, pp. 184-91, (2012) (PubMed).
: "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages." in: Virology, Vol. 420, Issue 1, pp. 32-42, (2011) (PubMed).
: "Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 51, pp. 17634-9, (2004) (PubMed).
: "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans." in: Cellular signalling, Vol. 15, Issue 6, pp. 565-74, (2003) (PubMed).
: "Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages." in: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10175-81, (2000) (PubMed).
: "An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo." in: The Journal of biological chemistry, Vol. 270, Issue 35, pp. 20832-40, (1995) (PubMed).
Synonyms and alternative names related to PDE8A
phosphodiesterase 8A (PDE8A), phosphodiesterase 8A (Pde8a), phosphodiesterase 8A (pde8a), AI551852, HsT19550, Pde8, PDE8A, Pde8a, RNPDE8AProtein level used designations for PDE8A
- phosphodiesterase 8A
- high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
- phosphodiesterase 8a
- high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A-like
- cAMP-specific cyclic nucleotide phosphodiesterase 8A
- mmPDE8
- cAMP-specific cyclic nucleotide phosphodiesterase PDE8
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