电话:
+1 877 302 8632
传真:
+1 888 205 9894 (Toll-free)
电子邮件:
orders@antibodies-online.cn

PDE4B 抗体

(phosphodiesterase 4B, cAMP-Specific (PDE4B))
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
PDE4B 抗体  (AA 500-736) PDE4B 抗体  (AA 500-736) PDE4B 抗体 (AA 500-736) (ABIN7442141)

PDE4B 适用: 大鼠 ICC, IHC, IP, WB 宿主: 兔 Polyclonal unconjugated

PDE4B 抗体  (C-Term) PDE4B 抗体  (C-Term) PDE4B 抗体 (C-Term) (ABIN185574)

Verified PDE4B 适用: 人, 小鼠 ELISA, IHC, WB 宿主: 山羊 Polyclonal unconjugated

PDE4B 抗体  (AA 27-215) PDE4B 抗体  (AA 27-215) PDE4B 抗体 (AA 27-215) (ABIN7146632)

PDE4B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

PDE4B 抗体 by Grade

Find PDE4B 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PDE4B 抗体 by 适用

Find PDE4B 抗体 for a variety of species such as anti-Human PDE4B, anti-Mouse PDE4B, anti-Rat PDE4B. The species listed below are among those available. Click on a link to go to the corresponding products.

PDE4B 抗体 by 应用范围

Find PDE4B 抗体 validated for a specific application such as WB, ELISA, FACS, IHC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PDE4B 抗体 by 抗体来源

Find PDE4B 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

PDE4B 抗体 by 抗原表位

Find PDE4B 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

PDE4B 抗体 by 克隆形成能力

Find available monoclonal or polyclonal PDE4B 抗体. Click on a link to go to the corresponding products.

PDE4B 抗体 by 克隆

Find PDE4B 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

PDE4B 抗体 by 标记

Find PDE4B 抗体 with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular PDE4B 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application ICC, IHC, IP, WB
Validations
  • (6)
Cat. No. ABIN7442141
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN185574
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7146632
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application FACS, WB
Validations
  • (2)
Cat. No. ABIN655630
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN2855498
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (2)
Cat. No. ABIN4904711
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN2786603
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application EIA, FACS, WB
Validations
  • (2)
Cat. No. ABIN954065
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6145350
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ICC, IF
Validations
  • (1)
Cat. No. ABIN2855496
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6746441
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Pig, Rat
Application IHC, IHC (p), WB
Validations
  • (1)
Cat. No. ABIN6755460
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application FACS, IF, IHC, IHC (p), WB
Validations
  • (1)
Cat. No. ABIN2582958
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IP, IHC, WB
Validations
  • (1)
Cat. No. ABIN341174
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), IP, WB
Validations
  • (1)
Cat. No. ABIN1042649
Quantity 50 μL
Datasheet Datasheet

Latest Publications for our PDE4B 抗体

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Johanns, Lai, Hsu, Jacobs, Vertommen, Van Sande, Dumont, Woods, Carling, Hue, Viollet, Foretz, Rider: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." in: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).

Cedervall, Aulabaugh, Geoghegan, McLellan, Pandit: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).

Nagy, Ross, Rodriguez, Balint, Szeles, Nagy, Kirken: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).

Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).

Barette, Jariel-Encontre, Piechaczyk, Piette: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).

Johnson, Walker: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).

Aliases for PDE4B 抗体

phosphodiesterase 4B (pde4b) 抗体
phosphodiesterase 4B (PDE4B) 抗体
phosphodiesterase 4B, cAMP specific (Pde4b) 抗体
phosphodiesterase 4B (Pde4b) 抗体
phosphodiesterase 4B S homeolog (pde4b.S) 抗体
dpde4 抗体
Dpde4 抗体
DPDE4 抗体
dunce 抗体
PDE4/IVb 抗体
Pde4B1 抗体
Pde4B2 抗体
Pde4B3 抗体
Pde4B4 抗体
pde4b5 抗体
PDE4B5 抗体
pdeivb 抗体
PDEIVB 抗体
R74983 抗体
You are here:
客服