PDE4B 抗体
(phosphodiesterase 4B, cAMP-Specific (PDE4B))
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| PDE4B 抗体 (AA 489-736) | 人 | 兔 Polyclonal |
|
|
|
| PDE4B 抗体 | 大鼠 | 小鼠 Monoclonal |
|
|
|
| PDE4B 抗体 (AA 103-153) | 人, 大鼠 | 兔 Polyclonal |
|
|
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 489-736
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 103-153
Latest Publications for our PDE4B 抗体
: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).
: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." in: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).
: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).
: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).
: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).
: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).
: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).
: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." in: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).
: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).
: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).
: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).
: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).
: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).
Aliases for PDE4B 抗体
phosphodiesterase 4B (pde4b) 抗体phosphodiesterase 4B (PDE4B) 抗体
phosphodiesterase 4B, cAMP specific (Pde4b) 抗体
phosphodiesterase 4B (Pde4b) 抗体
phosphodiesterase 4B S homeolog (pde4b.S) 抗体
dpde4 抗体
Dpde4 抗体
DPDE4 抗体
dunce 抗体
PDE4/IVb 抗体
Pde4B1 抗体
Pde4B2 抗体
Pde4B3 抗体
Pde4B4 抗体
pde4b5 抗体
PDE4B5 抗体
pdeivb 抗体
PDEIVB 抗体
R74983 抗体
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