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A deficiency of KLF2 (显示 KLF2 ELISA试剂盒) increased the expression of Notch ligand Jagged2 via hypoxia-inducible factor 1alpha (HIF-1alpha (显示 HIF1A ELISA试剂盒)), which led to Th2 amplification.
silencing prevents Notch2 (显示 NOTCH2 ELISA试剂盒)-driven osteoclast development and bone destruction in multiple myeloma
Although Jag1 (显示 JAG1 ELISA试剂盒) shares a high degree of homology with Jag2 in the ectodomain region, BACE1 (显示 BACE ELISA试剂盒) fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1 (显示 JAG1 ELISA试剂盒).
Reducing Jagged 1 (显示 JAG1 ELISA试剂盒) and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein (显示 MGP ELISA试剂盒) deficiency.
these findings suggest that Jagged2 signaling can affect graft acceptance by upregulation of IL-6 (显示 IL6 ELISA试剂盒) and consequent resistance to Treg-cell suppression.
results demonstrate that maternal P4 levels during midpregnancy can inhibit the expression of Jagged2 and Notch1 (显示 NOTCH1 ELISA试剂盒), which are involved in primordial folliculogenesis, in the mouse fetal ovary
These data suggest that Notch (显示 NOTCH1 ELISA试剂盒) ligands are differentially regulated in DCs: Delta-like (显示 DLK1 ELISA试剂盒) 4 is regulated by T helper cells and by pathogen-derived Th1 (显示 HAND1 ELISA试剂盒) stimuli, whereas Jagged 2 is regulated by Th2 cells and pathogen-derived Th2-promoting stimuli.
novel Jagged2/miR (显示 MLXIP ELISA试剂盒)-200-dependent pathway that mediates lung adenocarcinoma epithelial-to-mesenchymal transition and metastasis
Loss of Jagged2 is associated with craniofacial, limb, and T cell development.
Notch (显示 NOTCH1 ELISA试剂盒) ligands, including Delta-like1 and 3 and Jagged1 (显示 JAG1 ELISA试剂盒) and Jagged2, show distinct expression patterns in the developing and adult brain overlapping that of Notch1 (显示 NOTCH1 ELISA试剂盒)
In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039).
these results show that the Notch (显示 NOTCH1 ELISA试剂盒) signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 (显示 JAG1 ELISA试剂盒) or Jagged 2 on DCs is not required
The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2 (显示 NOTCH2 ELISA试剂盒), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (显示 NOTCH1 ELISA试剂盒) binding is likely to be critical in establishing the optimal context for Notch (显示 NOTCH1 ELISA试剂盒) signalling.
Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1
Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells
Increased expression of JAG2, a target of miR (显示 MLXIP ELISA试剂盒)-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma.
Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH (显示 NOTCH1 ELISA试剂盒) activation.
This study demonistrated that NOTCH (显示 NOTCH1 ELISA试剂盒) ligands JAG1 (显示 JAG1 ELISA试剂盒) and JAG2 as critical pro-survival factors in childhood medulloblastoma.
Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
Results indicate that Jagged-Notch (显示 NOTCH1 ELISA试剂盒) signaling is required for segregation between wt1 (显示 WT1 ELISA试剂盒)-expressing cells and differentiated steroidogenic tissue.
Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.
Mice homozygous for a deletion in the Notch (显示 NOTCH1 ELISA试剂盒)-interaction domain of Jag2 presented a variety of severe dental abnormalities.
Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
Jag2-mediated Notch (显示 NOTCH1 ELISA试剂盒) signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
, protein jagged-2-like
, protein jagged-2
, notch ligand