Use your antibodies-online credentials, if available.
抗Human ADAM17 抗体:
抗Mouse (Murine) ADAM17 抗体:
抗Rat (Rattus) ADAM17 抗体:
Human Monoclonal ADAM17 Primary Antibody for CyTOF, FACS - ABIN4900516
Breshears, Schlievert, Peterson: A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). in The Journal of biological chemistry 2012
Show all 8 Pubmed References
Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897863
Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012
Show all 5 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for IHC - ABIN965510
Rabie, Strehl, Ludwig, Nieswandt: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. in The Journal of biological chemistry 2005
Show all 12 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for ICC, ELISA - ABIN1003300
Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997
Show all 4 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for IHC, IHC (p) - ABIN4357504
Sharma, Bender, Zimmermann, Riesterer, Broggini-Tenzer, Pruschy: Secretome Signature Identifies ADAM17 as Novel Target for Radiosensitization of Non-Small Cell Lung Cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Human Polyclonal ADAM17 Primary Antibody for ICC, ELISA - ABIN1003301
Rosendahl, Ko, Long, Brewer, Rosenzweig, Hedl, Anderson, Pyle, Moreland, Meyers, Kohno, Lyons, Lichenstein: Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. in The Journal of biological chemistry 1997
Show all 3 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1531481
Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. in Neurobiology of disease 2015
Show all 3 Pubmed References
Human Monoclonal ADAM17 Primary Antibody for IHC (p), PLA - ABIN563080
Kahlert, Weber, Mogler, Bergmann, Schirmacher, Kenngott, Matterne, Mollberg, Rahbari, Hinz, Koch, Aigner, Weitz: Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. in British journal of cancer 2009
Human Polyclonal ADAM17 Primary Antibody for FACS, IF (p) - ABIN705671
Li, Xie, He, Wang, Duan, Yang, Wang: Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis. in Gene 2015
Human Polyclonal ADAM17 Primary Antibody for ICC, FACS - ABIN1030720
McGowan, Mullooly, Caiazza, Sukor, Madden, Maguire, Pierce, McDermott, Crown, ODonovan, Duffy: ADAM-17: a novel therapeutic target for triple negative breast cancer. in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013
A novel ADAM17 inhibitor ZLDI-8 may be a potential chemosensitizer which sensitized CRC (显示 CALR 抗体) cells to 5-fluorouracil or irinotecan by reversing Notch (显示 NOTCH1 抗体) and EMT (显示 ITK 抗体) pathways.
The isolated membrane proximal domain (MPD (显示 MVD 抗体)) of ADAM17 binds to phosphatidylserine (PS) but not to phosphatidylcholine (显示 SGMS2 抗体) liposomes. A cationic PS-binding motif is identified in this domain, replacement of which abrogates liposome-binding and renders the protease incapable of cleaving its substrates in cells.
ADAM-17 in inflammatory myopathy was significantly higher than that in healthy control. ADAM-17 in post-treatment with corticosteroid and/or immunosuppressant serum was significantly decreased compared with that in pre-treatment serum.
The present research suggests that ADAM17shRNA can inhibit MCF7 cell invasion and proliferation in vitro and inhibit MCF7 xenograft growth in vivo through the EGFR (显示 EGFR 抗体)/PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) and EGFR (显示 EGFR 抗体)/MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体) signaling pathways.
Uev1A (显示 UBE2V1 抗体)-Ubc13 (显示 UBE2N 抗体) complex catalyzes lysine63-linked ubiquitination of RHBDF2 (显示 RHBDF2 抗体) to promote TACE maturation.
ADAM17 plays a role in chronic kidney disease-mineral and bone disorder.
Insulin-like growth factor-1 (显示 IGF1 抗体) activates different catalytic subunits p110 (显示 CUX1 抗体) of PI3K (显示 PIK3CA 抗体) in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 (显示 ADAM10 抗体) and ADAM17.
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 (显示 TREM2 抗体) after Histidine 157. Findings reveal a link between shedding of TREM2 (显示 TREM2 抗体) and its regulation during inflammatory conditions or chronic neurodegenerative disease in which activity or expression of sheddases might be altered.
Oxidative stress is correlated with hyperactivation of the ADAM17/Notch (显示 NOTCH1 抗体) signaling pathway and a consequent increase in fibrosis in patients with endometriosis.
Plasma levels of ADAM17 are increased in Tanzanian children hospitalized with a malaria infection compared with asymptomatic children but similar to children hospitalized with other infectious diseases. The plasma levels of ADAM17 decreased during recovery after an acute malaria episode.
Report atheroprotective functions of ADAM17 in myeloid cells but atheroprogressive ADAM17 functions in endothelial cells.
results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.
iRhom2 (显示 RHBDF2 抗体) controls multiple aspects of TACE biology, including stimulated shedding on the cell surface.
Targeting ADAM17 with a lentiviral vector attenuates endotoxemia in mice.
Addition of a disintegrin and metallopeptidase domain 17 (ADAM17) to the culture supernatant of stimulated splenocytes decreased Interferon-gamma (IFN-gamma (显示 IFNG 抗体)) concentration.
Overall, iRhom2 (显示 RHBDF2 抗体) binds to TACE throughout its lifecycle, implying that iRhom2 (显示 RHBDF2 抗体) is a primary regulator of stimulated cytokine and growth factor signalling.
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR (显示 EGFR 抗体)-ligands by differentially activating ADAM17 or ADAM10 (显示 ADAM10 抗体).
Fhl2 (显示 FHL2 抗体) anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF (显示 TNF 抗体)
most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR (显示 EGFR 抗体)
ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms
these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha (显示 TNF 抗体), which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
ADAM17 was involved in porcine CD16 (显示 CD16 抗体) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (显示 CD163 抗体) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (显示 FYN 抗体)-induced c-Src (显示 SRC 抗体)-dependent manner mediates proteolytic activation of the EGF (显示 EGF 抗体)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (显示 TNF 抗体) stimulates Rac (显示 AKT1 抗体), ADAM17/TACE, and RhoA (显示 RHOA 抗体) through the guanine nucleotide exchange factor (显示 ARHGEF12 抗体) (GEF)-H1 (显示 ARHGEF2 抗体).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (显示 EGF 抗体) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 18
, TNF-alpha convertase
, TNF-alpha converting enzyme
, disintegrin and metalloproteinase domain-containing protein 17
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme
, ADAM 17
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, tumor necrosis factor alpha converting enzyme
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM metallopeptidase domain 17a
, a disintegrin and metalloproteinase domain 17a