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ADAM17 抗体 (C-Term)

Name: ADAM17 抗体 (C-Term)
SKU: ABIN500861
Availability: OutOfStock

ADAM17 适用: 人, 大鼠, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of TACE in HeLa (1,3) and Jurkat (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide with TACE Antibody at 1 μg/ml.

Immunofluorescence of TACE in HeLa cells with TACE at 10 µg/ml.

Immunocytochemistry of TACE in HeLa cells with TACE Antibody AP30854PU-N at 10 µg/ml.

3 images

(1 reference)

产品编号 ABIN500861

发货至: 中国

Datasheet as PDF

抗原 See all ADAM17 抗体

ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
抗原表位
16

13

12

8

8

7

6

5

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
114

53

51

4

4

4

1

1
人, 大鼠, 小鼠
宿主
99

13

2

1

1
兔
Compatible Secondaries
克隆类型
91

25
多克隆
标记
53

11

8

6

5

5

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1
This ADAM17 antibody is un-conjugated
应用范围
86

53

40

15

14

14

11

11

10

6

4

4

3

2

2
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

特异性

This antibody detects CD156b / ADAM17 at C-term. 80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated CD156b.

交叉反应（详细）

Species reactivity (tested):Human, Mouse, Rat.

纯化方法

Immunoaffinity Chromatography

免疫原

A peptide corresponding to amino acids near the carboxy terminus of Human CD156b / ADAM17

亚型

IgG

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anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 201-300) antibody
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anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 226-473) antibody
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anti-ADAM Metallopeptidase Domain 17 (ADAM17) (C-Term) antibody
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anti-ADAM Metallopeptidase Domain 17 (ADAM17) (C-Term) antibody
KO Validated ADAM17 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-ADAM Metallopeptidase Domain 17 (ADAM17) antibody
ADAM17 适用: 人, 大鼠, 小鼠 WB, FACS, IF (cc) 宿主: 兔 Monoclonal 9E7 unconjugated

anti-ADAM Metallopeptidase Domain 17 (ADAM17) (pThr735) antibody
ADAM17 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-ADAM Metallopeptidase Domain 17 (ADAM17) (N-Term) antibody
ADAM17 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated

anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-315) antibody
ADAM17 适用: 人 WB, ELISA, IHC, IHC (p), PLA 宿主: 小鼠 Monoclonal 1F6 unconjugated

应用备注

ELISA. Western blot: 1: 500 to 1: 2000. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
缓冲液

PBS containing 0.02 % Sodium Azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Wang, Wang, Yin, Zhang, Yu, Kong, Yuan, Fang, Liu, Liu, Shi: "Reduced neurotrophic factor level is the early event before the functional neuronal deficiency in high-fat diet induced obese mice." in: Metabolic brain disease, Vol. 32, Issue 1, pp. 247-257, (2018) (PubMed).
抗原

ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

别名

CD156b / ADAM17 (ADAM17 产品)

别名

ADAM18 antibody, CD156B antibody, CSVP antibody, NISBD antibody, TACE antibody, CD156b antibody, Tace antibody, adam17 antibody, si:dkey-81b15.2 antibody, adam18 antibody, cd156b antibody, csvp antibody, tace antibody, fc20b01 antibody, wu:fc20b01 antibody, zgc:63886 antibody, ADAM metallopeptidase domain 17 antibody, a disintegrin and metallopeptidase domain 17 antibody, ADAM metallopeptidase domain 17b antibody, ADAM metallopeptidase domain 17 L homeolog antibody, ADAM metallopeptidase domain 17a antibody, ADAM17 antibody, Adam17 antibody, adam17b antibody, adam17.L antibody, adam17a antibody

背景

Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-alpha is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-alpha. TNF-alpha converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.Synonyms: CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme

基因ID

6868

NCBI登录号

NP_003174

途径

Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus