NFATC1 产品
(Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))
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The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008].
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Featured NFATC1 Categories
NFATC1 抗体
High quality antibodies with extensive validation data.
NFATC1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
NFATC1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NFATC1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (8)
Cat. No.
ABIN3022101
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN686257
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA, IF
Validations
- (2)
Cat. No.
ABIN7161789
Quantity
100 μg
Datasheet
Datasheet
Recommended NFATC1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968983
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968984
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958238
Quantity
96 tests
Datasheet
Datasheet
Recommended NFATC1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312441
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312440
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3094169
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NFATC1 Products
: "PTPN22 interacts with EB1 to regulate T-cell receptor signaling." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, (2020) (PubMed).: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." in: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).
: "α-Linolenic Acid Inhibits Receptor Activator of NF-κB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible ..." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 5056-5069, (2018) (PubMed).
: "TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways." in: Scientific reports, Vol. 6, pp. 29041, (2016) (PubMed).
: "Phospho-sulindac inhibits pancreatic cancer growth: NFATc1 as a drug resistance candidate." in: International journal of oncology, Vol. 44, Issue 2, pp. 521-9, (2013) (PubMed).
: "Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1." in: Hepatology (Baltimore, Md.), Vol. 53, Issue 2, pp. 628-39, (2011) (PubMed).
: "Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling." in: The American journal of pathology, Vol. 172, Issue 1, pp. 215-24, (2008) (PubMed).
: "Autoamplification of NFATc1 expression determines its essential role in bone homeostasis." in: The Journal of experimental medicine, Vol. 202, Issue 9, pp. 1261-9, (2005) (PubMed).
: "The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production." in: Immunity, Vol. 8, Issue 1, pp. 115-24, (1998) (PubMed).
: "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT." in: Molecular cell, Vol. 1, Issue 5, pp. 627-37, (1998) (PubMed).
Synonyms and alternative names related to NFATC1
nuclear factor of activated T-cells 1 (NFATC1), nuclear factor of activated T-cells 1 L homeolog (nfatc1.L), nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (nfatc1), nuclear factor of activated T-cells 1 (nfatc1), nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 (Nfatc1), nuclear factor of activated T-cells 1 (Nfatc1), 2210017P03Rik, AI449492, AV076380, nf-atc, NF-ATc, NF-ATC, NF-ATc1, NFAT, nfat2, NFAT2, nfatc, NFATc, NFATC1, Nfatcb, NFATmac, si:ch211-198c22.2Protein level used designations for NFATC1
- nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
- nuclear factor of activated T-cells, cytosolic component 1
- nuclear factor of activated T-cells calcineurin-dependent 1
- nuclear factor of activated T-cells, cytoplasmic 1
- nuclear factor of activated T-cells, cytoplasmic 1-like
- NF-ATc1
- NFAT transcription complex cytosolic component
- transcription factor NF-ATc
- NFATc
- transcription factor NFATmac
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