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NFAT1 产品

(Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012].

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Featured NFAT1 Categories

NFAT1 抗体

High quality antibodies with extensive validation data.

NFAT1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

NFAT1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NFAT1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN3017385
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (2)
Cat. No. ABIN6972419
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN571020
Quantity 100 μg
Datasheet Datasheet

Recommended NFAT1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6958239
Quantity 96 tests
Datasheet Datasheet

Recommended NFAT1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312443
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135265
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094115
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our NFAT1 Products

Sun, Liu, Geng, Tao, Zheng, Wang, Fu, Wang, Xie, Zhang, Gong: "The elevated serum levels of calcineurin and nuclear factor of activated T-cells 1 in children with Kawasaki disease." in: Pediatric rheumatology online journal, Vol. 18, Issue 1, pp. 23, (2020) (PubMed).

Song, Carr, McDermott, Rodriguez, Babicheva, Balistrieri, Ayon, Wang, Makino, Yuan: "STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension." in: Hypertension (Dallas, Tex. : 1979), Vol. 71, Issue 3, pp. 518-529, (2018) (PubMed).

Bai, Li, Wang, Lian, Wang: "The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB." in: International journal of molecular medicine, Vol. 40, Issue 1, pp. 155-163, (2018) (PubMed).

Perotti, Baldassari, Molla, Vegetti, Bersani, Maurichi, Santinami, Anichini, Mortarini: "NFATc2 is an intrinsic regulator of melanoma dedifferentiation." in: Oncogene, Vol. 35, Issue 22, pp. 2862-72, (2016) (PubMed).

Liu, Han, Han, He: "Mesenchymal stem cell-conditioned media suppresses inflammation-associated overproliferation of pulmonary artery smooth muscle cells in a rat model of pulmonary hypertension." in: Experimental and therapeutic medicine, Vol. 11, Issue 2, pp. 467-475, (2016) (PubMed).

Quang, Leboucher, Passaro, Fuhrmann, Nourieh, Vincent-Salomon, Ghysdael: "The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells." in: Cell death & disease, Vol. 6, pp. e1658, (2015) (PubMed).

Scanlon, Banerjee, Inglehart, Liu, Russo, Hariharan, van Tubergen, Corson, Asangani, Mistretta, Chinnaiyan, DSilva: "Galanin modulates the neural niche to favour perineural invasion in head and neck cancer." in: Nature communications, Vol. 6, pp. 6885, (2015) (PubMed).

Cotroneo, Ashek, Wang, Wharton, Dubois, Bozorgi, Busbridge, Alavian, Wilkins, Zhao: "Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat." in: Circulation research, Vol. 116, Issue 10, pp. 1680-90, (2015) (PubMed).

Lawrence, Borenstein-Auerbach, McGlynn, Kunnathodi, Shahbazov, Syed, Kanak, Takita, Levy, Naziruddin: "NFAT targets signaling molecules to gene promoters in pancreatic β-cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 29, Issue 2, pp. 274-88, (2015) (PubMed).

Iampietro, Morissette, Gravel, Flamand: "Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein." in: Journal of virology, Vol. 88, Issue 21, pp. 12452-63, (2014) (PubMed).

Synonyms and alternative names related to NFAT1

nuclear factor of activated T-cells 2 (NFATC2), nuclear factor of activated T-cells 2 (nfatc2), nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 (Nfatc2), nuclear factor of activated T-cells 2 (Nfatc2), AI607462, NF-ATc2, NFAT1, NFAT1-D, NFATC2, Nfatp, NFATP

Protein level used designations for NFAT1

  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
  • nuclear factor of activated T-cells, cytoplasmic 2-like
  • NF-ATp
  • NFAT pre-existing subunit
  • T-cell transcription factor NFAT1
  • nuclear factor of activated T-cells, cytoplasmic 2
  • NF-ATc2
  • NFAT transcription complex, preexisting component
  • T cell transcription factor NFAT1
  • nuclear factor of activated T-cells, preexisting component
  • preexisting nuclear factor of activated T-cells 2
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