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抗Human PRKACA 抗体:
抗Rat (Rattus) PRKACA 抗体:
抗Mouse (Murine) PRKACA 抗体:
Human Polyclonal PRKACA Primary Antibody for ELISA, WB - ABIN562366
Adachi, Kano, Saido, Murata: Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion. in Genes to cells : devoted to molecular & cellular mechanisms 2009
Human Polyclonal PRKACA Primary Antibody for ICC, IF - ABIN408069
Enns, Morton, Mangalindan, McKnight, Schwartz, Kaeberlein, Kennedy, Rabinovitch, Ladiges: Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. in The journals of gerontology. Series A, Biological sciences and medical sciences 2009
CaV1.4 (显示 CACNA1F 抗体) channels are indeed modulated by PKA phosphorylation within the inhibitor of Ca(2 (显示 CA2 抗体)+)-dependent inactivation (ICDI) motif.
In this study, the authors linked for the first time the loss of RIIbeta (显示 PRKAR2B 抗体) protein levels to the PRKACA mutation status and found the down-regulation of RIIbeta (显示 PRKAR2B 抗体) to arise post-transcriptionally.
the presence of lipofuscin in cortisol-producing adenomas (CPAs) responsible for Cushing syndrome with and without the PRKACA (pLeu206Arg) somatic mutation, was investigated.
Mechanistically, Sirt1 (显示 SIRT1 抗体) expression elevates phosphorylation of the alpha subunit (显示 POLG 抗体) of protein kinase A (PKA alpha), and this event is essential for Sirt1 (显示 SIRT1 抗体)-induced phosphorylation of beta Catenin (显示 CTNNB1 抗体).
Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 (显示 ARPP19 抗体) by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A (显示 PPP2R4 抗体) disinhibition.
CTR (显示 CALCR 抗体) activates AKAP2 (显示 AKAP2 抗体)-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 (显示 TJP1 抗体) and claudin 3 (显示 CLDN3 抗体).
These results indicate that Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC (显示 FAM126A 抗体)) is similar to pure FL-HCC (显示 FAM126A 抗体) at the genomic level and the DNAJB1 (显示 DNAJB1 抗体):PRKACA fusion can be used as a diagnostic tool for both pure and mFL-HCC (显示 FAM126A 抗体)
PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are affected by a more severe phenotype and are identified at a younger age.
Somatic mutations in PRKACA, coding for the catalytic alpha subunit (显示 POLG 抗体) of protein kinase A (PKA), have been recently identified as the most frequent genetic alteration in cortisol-secreting adrenocortical adenomas, which are responsible for adrenal Cushing's syndrome.
HIF1a (显示 HIF1A 抗体) transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.
structural basis of selectivity for protein kinase A in complex with Rho-kinase (显示 ROCK1 抗体) inhibitors by x-ray crystallography
Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.
ceramide as a potent physiological modulator of the Na(+)-ATPase (显示 DNAH8 抗体), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (显示 PRKCZ 抗体)
we demonstrate that PKA, PKC (显示 FYN 抗体) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (显示 GSK3a 抗体) phosphorylation which subsequently controls cell motility.
Study validates the DNAJB1 (显示 DNAJB1 抗体)-PRKACA fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin (显示 CTNNB1 抗体).
Protein kinase A signaling explains vasopressin (显示 AVP 抗体)-mediated regulation of membrane trafficking and gene transcription.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB (显示 CREB1 抗体) signaling.
Generation of the Dnajb1 (显示 DNAJB1 抗体)-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma.
Data indicate a subpopulation of the CaV1.2 (显示 CACNA1C 抗体) channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (显示 SCP2 抗体)), a form of synaptic plasticity that requires Cav1.2 (显示 CACNA1C 抗体) and enhancement of its activity by the beta2-adrenergic receptor (显示 ADRB2 抗体) (beta2AR (显示 ADRB2 抗体))-cAMP-PKA cascade.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (显示 NRG1 抗体) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
study identifies a new role of Dual-AKAP1 (显示 AKAP1 抗体) in regulating mitochondrial trafficking through Miro-2 (显示 RHOT2 抗体), and supports a model in which PINK1 (显示 PINK1 抗体) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
support hypothesis that PRKACA activation is responsible for downstream protein tyrosine phosphorylation events in stallion sperm
Thus Ca(2 (显示 CA2 抗体)+)-cAMP/PKA-dependent phosphorylation limits the rate and magnitude of increase in spontaneous action potential firing rate.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
, cAMP-dependent protein kinase catalytic subunit alpha
, protein kinase A catalytic subunit
, cAMP-dependent protein kinase catalytic subunit C alpha
, protein kinase A
, protein kinase, cAMP-dependent, catalytic, alpha
, C-alpha subunit
, sperm cAMP-dependent protein kinase catalytic subunit
, protein kinase A alpha
, PKA catalytic subunit alpha