Use your antibodies-online credentials, if available.
抗Human PKC zeta 抗体:
抗Mouse (Murine) PKC zeta 抗体:
抗Rat (Rattus) PKC zeta 抗体:
Human Polyclonal PKC zeta Primary Antibody for IHC (p) - ABIN2476259
Hirai, Chida: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. in Journal of biochemistry 2003
Human Polyclonal PKC zeta Primary Antibody for IHC (p), WB - ABIN391018
Lerner-Marmarosh, Miralem, Gibbs, Maines: Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Human Polyclonal PKC zeta Primary Antibody for ICC, IF - ABIN4345863
Verbist, Guy, Milasta, Liedmann, Kamiński, Wang, Green: Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. in Nature 2016
Protein kinase c activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
We also carried out PKC (显示 PRRT2 抗体)-iota and PKC-zeta directed siRNA treatments to prove the above observations. Immunoprecipitation data suggested an association between PKC (显示 PRRT2 抗体)-iota and vimentin (显示 VIM 抗体) and PKC (显示 PRRT2 抗体)-iota siRNA treatments confirmed that PKC (显示 PRRT2 抗体)-iota activates vimentin (显示 VIM 抗体) by phosphorylation. These results further suggested that PKC (显示 PRRT2 抗体)-iota is involved in signaling pathways which upregulate EMT (显示 ITK 抗体) and which can be effectively suppressed using A...
PKCzeta promoted lung adenocarcinoma invasion and metastasis, and its expression was associated with MMP2 (显示 MMP2 抗体) and MMP9 (显示 MMP9 抗体) expression.
PKC-zeta may be responsible for the abnormal growth, proliferation, and migration of metastatic LOVO colon cancer cells via PKC-zeta/Rac1 (显示 RAC1 抗体)/Pak1 (显示 PAK1 抗体)/beta-Catenin (显示 CTNNB1 抗体) pathway.
reduced expression of PKCzeta/Pard3 (显示 PARD3 抗体)/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine (显示 SGMS2 抗体) remarkably attenuated gut (显示 GUSB 抗体) injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2 (显示 TRAF2 抗体), which was phosphorylated by PKCzeta at Ser (显示 SIGLEC1 抗体)(55), but not at Ser (显示 SIGLEC1 抗体)(11), under intestinal I/R or H/R conditions
these results conclude that miR (显示 MLXIP 抗体)-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK (显示 PRKAA1 抗体) signaling.
PKCzeta was specifically involved in ACOT7 (显示 ACOT7 抗体) depletion-mediated cell cycle arrest as an upstream molecule of the p53 (显示 TP53 抗体)-p21 (显示 CDKN1A 抗体) signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
we found that Wnt3a (显示 WNT3A 抗体) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (显示 DVL2 抗体) and Dvl3 (显示 DVL3 抗体). Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl (显示 DVL2 抗体) signaling activity, to produce a strong and sustained response to Wnt3a (显示 WNT3A 抗体) treatment by stabilizing Dvl (显示 DVL2 抗体) protein levels.
The data demonstrate that PKCzeta expression regulates the maturation of neonatal T-cells into specific functional phenotypes and that environmental influences may work via PKCzeta to regulate these phenotypes and disease susceptibility.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (显示 GPR39 抗体) to enhance the abundance of ZO-1 (显示 TJP1 抗体), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
protein kinase M zeta expression in the anterior cingulate cortex is enhanced by peripheral nerve injury in a transcription-independent manner.
this study elucidates the role of the aPKC-CBP (显示 CREBBP 抗体) pathway in modulating neurovascular remodeling and functional recovery following focal ischemic stroke.
HIF regulation of HOIL-1L (显示 RBCK1 抗体) targets the phosphorylated PKC-zeta for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase (显示 ATP1A1 抗体), avoiding significant lung injury.
Under physiological conditions, PKMzeta is the principal PKC isoform that maintains LTP (显示 SCP2 抗体) and long-term memory. PKCiota/lambda can compensate for PKMzeta, and because other isoforms could also maintain synaptic facilitation, there may be a hierarchy of compensatory mechanisms maintaining memory if PKMzeta malfunctions. [Review]
aPKCzeta is required for the cellular organization of acto-non-muscle myosin II (NMII) cytoskeleton, for proper cell adhesion and directed cell migration.
This study demonstrates that the combination therapy of PKCzeta and COX-2 (显示 COX2 抗体) inhibitors can significantly inhibit melanoma metastasis in vitro and in vivo, which will be an efficient strategy for treatment of melanoma metastasis in clinics
the inhibition of PKCzeta or ceramide synthesis did not further improve glucose tolerance in Angptl4 (显示 ANGPTL4 抗体)(-/-) mice, suggesting that these molecules were major downstream effectors of Angptl4 (显示 ANGPTL4 抗体).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 (显示 SP1 抗体) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
APPL1 (显示 APPL1 抗体) enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A (显示 PPP2R2B 抗体) and myosin IIa.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (显示 ANGPT1 抗体), via phosphorylation of eNOS (显示 NOS3 抗体) on Thr (显示 TRH 抗体)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (显示 VEGFA 抗体)-stimulated endothelial permeability by Ang-1 (显示 ANGPT1 抗体).
ceramide as a potent physiological modulator of the Na(+)-ATPase (显示 DNAH8 抗体), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta