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抗Human PKC zeta 抗体:
抗Mouse (Murine) PKC zeta 抗体:
抗Rat (Rattus) PKC zeta 抗体:
Human Polyclonal PKC zeta Primary Antibody for ICC, IF - ABIN4345863
Verbist, Guy, Milasta, Liedmann, Kamiński, Wang, Green: Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. in Nature 2016
Human Polyclonal PKC zeta Primary Antibody for IHC (p) - ABIN2476259
Hirai, Chida: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. in Journal of biochemistry 2003
Human Polyclonal PKC zeta Primary Antibody for IHC (p), WB - ABIN391018
Lerner-Marmarosh, Miralem, Gibbs, Maines: Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Protein kinase c (显示 PKC 抗体) activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine (显示 SGMS2 抗体) remarkably attenuated gut (显示 GUSB 抗体) injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2 (显示 TRAF2 抗体), which was phosphorylated by PKCzeta at Ser (显示 SIGLEC1 抗体)(55), but not at Ser (显示 SIGLEC1 抗体)(11), under intestinal I/R or H/R conditions
these results conclude that miR (显示 MLXIP 抗体)-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK (显示 PRKAA1 抗体) signaling.
PKCzeta was specifically involved in ACOT7 (显示 ACOT7 抗体) depletion-mediated cell cycle arrest as an upstream molecule of the p53 (显示 TP53 抗体)-p21 (显示 CDKN1A 抗体) signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
we found that Wnt3a (显示 WNT3A 抗体) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (显示 DVL2 抗体) and Dvl3 (显示 DVL3 抗体). Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl (显示 DVL2 抗体) signaling activity, to produce a strong and sustained response to Wnt3a (显示 WNT3A 抗体) treatment by stabilizing Dvl (显示 DVL2 抗体) protein levels.
The data demonstrate that PKCzeta expression regulates the maturation of neonatal T-cells into specific functional phenotypes and that environmental influences may work via PKCzeta to regulate these phenotypes and disease susceptibility.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (显示 GPR39 抗体) to enhance the abundance of ZO-1 (显示 TJP1 抗体), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 (显示 IL4 抗体) and interleukin-10 (显示 IL10 抗体)
Here we provide the first evidence that PKC-zeta is a potential target for the treatment of COPD (显示 ARCN1 抗体) by selective small molecules
Study provides evidence for a novel PKC-zeta to p47phox interaction that is required for cell transformation from blebbishields and ROS (显示 ROS1 抗体) production in cancer cells.
FRET-based translocation assays reveal that insulin (显示 INS 抗体) promotes the association of both p62 (显示 GTF2H1 抗体) and aPKC with the insulin (显示 INS 抗体)-regulated scaffold IRS-1 (显示 IRS1 抗体).
This study demonstrates that the combination therapy of PKCzeta and COX-2 (显示 COX2 抗体) inhibitors can significantly inhibit melanoma metastasis in vitro and in vivo, which will be an efficient strategy for treatment of melanoma metastasis in clinics
the inhibition of PKCzeta or ceramide synthesis did not further improve glucose tolerance in Angptl4 (显示 ANGPTL4 抗体)(-/-) mice, suggesting that these molecules were major downstream effectors of Angptl4 (显示 ANGPTL4 抗体).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 (显示 SP1 抗体) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
APPL1 (显示 APPL1 抗体) enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A (显示 PPP2R2B 抗体) and myosin IIa.
Findings indicate PDZRN3 (显示 PDZRN3 抗体) regulates vascular permeability through a PKCzeta-containing complex.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (显示 INS 抗体) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (显示 FRAP1 抗体) protein) and Ccnd2 (cyclin-D2 (显示 CCND2 抗体)).
androstenedione administration increased Akt1 (显示 AKT1 抗体) and PKC zeta phosphorylation in the muscle tissue of C57BL6 mice.
studies support a model wherein an alternative mechanism regulates PKCzeta-mediated insulin (显示 INS 抗体) signalling that does not utilize conventional activation via agonist-evoked phosphorylation at the activation loop
PKCzeta/p62 (显示 GTF2H1 抗体) activation stimulated inflammatory cytokine production and enhanced IGF-I (显示 IGF1 抗体)-stimulated VSMC proliferation
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (显示 ANGPT1 抗体), via phosphorylation of eNOS (显示 NOS3 抗体) on Thr (显示 TRH 抗体)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (显示 VEGFA 抗体)-stimulated endothelial permeability by Ang-1 (显示 ANGPT1 抗体).
ceramide as a potent physiological modulator of the Na(+)-ATPase (显示 DNAH8 抗体), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta