Use your antibodies-online credentials, if available.
component of Reelin (显示 RELN 蛋白) signaling that acts predominantly by facilitating the VLDLR (显示 VLDLR 蛋白)-Dab1 (显示 DAB1 蛋白) axis to direct neuronal migration in the cortex and hippocampus and to augment synaptic plasticity
Immunohistochemistry and histological and morphometric analyses revealed a twofold increase in proliferative endothelial cells and a 1.35-fold increase in proliferative alpha-smooth muscle actin (显示 ACTG2 蛋白)-positive cells in the lungs of ITSN-deficient mice.
PRRT2 (显示 PRRT2 蛋白) interacts with the Src (显示 SRC 蛋白) homology 3 domain-bearing protein Intersectin 1, an intracellular protein (显示 CKAP2 蛋白) involved in synaptic vesicle cycling.
Endocytic deficiency caused by ITSN knock-down modified Alk5 (显示 TGFBR1 蛋白) endocytic trafficking and enhances its degradation
It was concluded that miR (显示 MLXIP 蛋白)-194 regulates ROMK (显示 KCNJ1 蛋白) channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis.
ITSN1 enhances Cbl (显示 CBL 蛋白) activity, in part, by modulating the interaction of Cbl (显示 CBL 蛋白) with Spry2 (显示 SPRY2 蛋白) through recruitment of Shp2 (显示 PTPN11 蛋白) phosphatase to the Cbl (显示 CBL 蛋白)-Spry2 (显示 SPRY2 蛋白) complex.
This study demonistrated that Itsn1 mutant mice showed severe deficits in Morris water maze and contextual fear memory tasks.
ITSN1 binds Pro-rich regions in both Cbl (显示 CBL 蛋白) and Spry2 (显示 SPRY2 蛋白), and interaction of ITSN1 with Spry2 (显示 SPRY2 蛋白) disrupts Spry2 (显示 SPRY2 蛋白)-Cbl (显示 CBL 蛋白) interaction, resulting in enhanced ubiquitylation of the EGFR (显示 EGFR 蛋白).
Data show that intersectin-SH3D interacts directly with a small region of CdGAP highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif.
Swapping of SH3 domain binding partners might act as a switch controlling the actin nucleation activity of intersectin 1L.
WIP (显示 WIPF1 蛋白) enhances the interaction of N-WASP with ITSN1 and promotes ITSN1/beta-actin (显示 ACTB 蛋白) association.
Here, we discover that intersectin-s binds DENND2B (显示 ST5 蛋白), a guanine nucleotide exchange factor (显示 RASGRF1 蛋白) for the exocytic GTPase (显示 RACGAP1 蛋白) Rab13 (显示 RAB13 蛋白), and this interaction promotes recycling of ligand-free EGFR (显示 EGFR 蛋白) to the cell surface. Our study thus reveals a novel mechanism controlling the fate of internalized EGFR (显示 EGFR 蛋白) with important implications for cancer.
study reports that vaccinia virus A36 contains three NPF motifs that interact with the Eps15 (显示 EPS15 蛋白) homology (EH) domains in intersectin-1 and Eps15 (显示 EPS15 蛋白) to promote the release of virus from infected cells and their subsequent spread
Silencing ITSN1 in neuroblastoma (显示 ARHGEF16 蛋白) cells led to decreased tumor growth in an orthotopic mouse model. Orthotopic animal models can provide insight into the role of ITSN1 pathways in neuroblastoma (显示 ARHGEF16 蛋白) tumorigenesis.
These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
Study suggests critical roles of ITSN1-S in malignant glioma proliferation, indicating a potential usage of ITSN1-S in the therapeutic intervention as a novel molecular target
Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation
ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
Silencing ITSN1 significantly inhibits the anchorage independent growth of tumor cells in vitro.
the neuron-specific isoform of the stable tubule-only polypeptide (显示 MAP6 蛋白) (STOP) interacts with SH3A domain of ITSN1.
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
, intersectin 1
, intersectin 1, isoform 1
, EH and SH3 domains protein 1
, Eh domain, SH3 domain regulator of endocytosis 1
, intersectin (SH3 domain protein 1A)
, intersectin short form 2 variant 2
, SH3 domain-containing protein 1A
, Src homology 3 domain-containing protein
, human intersectin-SH3 domain-containing protein SH3P17
, intersectin 1 short form variant 3
, intersectin 1 short form variant, 11
, intersectin short variant 12
, EH domain and SH3 domain regulator of endocytosis 1
, intersectin 1 (SH3 domain protein 1A)