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Data suggest that RGS16 functions as a GAP (GTPase (显示 RACGAP1 蛋白) accelerating protein) in the SCN (显示 SRI 蛋白) (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW]
The data establish miR (显示 MLXIP 蛋白)-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 (显示 CXCR4 蛋白) signaling by inhibition of RGS16.
suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16
these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells.
Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.
cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 (显示 KDM1A 蛋白) and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy.
Missense mutations in RGS16 gene is associated with breast cancer.
RGS16 and FosB (显示 FOSB 蛋白) are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival
Increased RGS16 levels are associated with colorectal cancer.
Src (显示 SRC 蛋白) mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability.
This study reveals how RGS (显示 PITX2 蛋白) proteins modulate Galphai2 (显示 GNAI2 蛋白) signaling to facilitate thymocyte egress and T cell trafficking.
Findings indicate that regulator of G-protein signaling 16 (RGS16) plays an important role in platelet function by modulating CXCL12 (显示 CXCL12 蛋白)-dependent platelet activation.
RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-mediated pulmonary inflammation.
Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm.
RGS16 provides a signaling mechanism for glucose production to inhibit GPCR-stimulated fatty acid oxidation in hepatocytes
The present study suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s).
Rgs16 and Rgs8 (显示 RGS8 蛋白) are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults.
Data show that knockdown of TNFR (显示 TNFRSF1A 蛋白)-associated factor 6 or NF-kappaB (显示 NFKB1 蛋白) activator 1 in 70Z/3 pre-B cells led to decreased Rgs16 expression, indicating that both of these two genes are involved in IL-17 (显示 IL17A 蛋白)-mediated activation of NF-kappaB (显示 NFKB1 蛋白) signaling in B cells.
results suggest that the amino-terminal palmitoylation of regulator of G-protein signaling 16 protein(RGS16) promotes its lipid raft targeting that allows palmitoylation of a poorly accessible cysteine residue
RGS16 expression in T lymphocytes results in selective blockade of T cell migration to certain chemokines and enhancement of T cell cytokine synthesis in response to a complex inflammatory stimulus.
Facilitated degradation of the RGS16 by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 (显示 IL6 蛋白) and IL-8 (显示 IL8 蛋白) mRNA transcripts.
The role of RGS16 in porcine circovirus infections via its binding with a nonstructural protein encoded by open reading frame 3 is reported.
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.
, regulator of G-protein signalling 16
, retinal-specific RGS
, retinally abundant regulator of G-protein signaling
, regulator of G-protein signaling 16
, regulators of G protein signaling XRGSI
, Regulator of G-protein signaling 16