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Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor (显示 CHRM3 抗体) signaling.
PhLP1 binding stabilizes the Gbeta (显示 SUCLG2 抗体) fold, disrupting interactions with CCT (显示 FLVCR2 抗体) and releasing a PhLP1-Gbeta (显示 SUCLG2 抗体) dimer for assembly with Ggamma.
During corticogenesis, a cilium-transduced, noncanonical IGF-1R (显示 IGF1R 抗体)-Gbetagamma-phospho(T94)Tctex-1 (显示 DYNLT1 抗体) signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
WDR26 (显示 WDR26 抗体) is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
Gbetagamma subunits enter in a protein complex with activated Rap1a (显示 RAP1A 抗体) and its effector Radil (显示 Radil 抗体); this complex is required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness.
G protein betagamma subunits stimulate type V and VI adenylyl cyclases
Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF (显示 HBEGF 抗体), which sequentially activates EGFR (显示 EGFR 抗体) and p38 (显示 CRK 抗体)
ectopically expressed cTalpha (显示 PCYT1A 抗体) 1) forms a heterotrimeric complex with rod Gbeta (显示 SUCLG2 抗体)(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin (显示 RHO 抗体) or S-cone opsin (显示 RHO 抗体)
Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o (显示 GNAO1 抗体)) upon activation of mGluR6 (显示 GRM6 抗体) closes the TRPM1 (显示 TRPM1 抗体) channel, perhaps via a direct interaction.
findings demonstrate that transducin (显示 GNAT1 抗体) betagamma-complex controls signal amplification of the rod phototransduction cascade and is critical for the ability of rod photoreceptors to function in low light conditions.
The PIP2-induced orientation of the GRK2 (显示 ADRBK1 抗体)-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 (显示 ADRBK1 抗体) PH domain.
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
guanine nucleotide-binding protein G(T) subunit gamma-T1
, transducin gamma chain
, guanine nucleotide binding protein (G protein), gamma 1 subunit
, gngt1 gene for guanine nucleotide binding protein (G protein) gamma 1 subunit
, rod transducin
, guanine nucleotide binding protein, gamma transducing activity polypeptide 1