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We provide evidence that the downregulation of hsa (显示 CD24 蛋白)-miR (显示 MLXIP 蛋白)-124-3p, hsa (显示 CD24 蛋白)-miR (显示 MLXIP 蛋白)-129-5p and hsa (显示 CD24 蛋白)-miR (显示 MLXIP 蛋白)-378 induced an increase in both expression and activity of CPT1A (显示 CPT1A 蛋白), CACT (显示 SLC25A20 蛋白) and CrAT in malignant prostate cells.
CrAT turned out to be active towards some but not all the BCAAO intermediates tested and no activity was found with dicarboxylic acyl-CoA (显示 GNPAT 蛋白) esters.
the purification, crystallization and preliminary X-ray crystallographic studies of human carnitine acetyltransferase are reported
structure of a binary complex of human peroxisomal carnitine acetyltransferase and the substrate l-carnitine, refined to a resolution of 1.8; site-directed mutagenesis and kinetic characterization
Data show that CrAT overexpression in primary human skeletal myocytes increased glucose uptake and attenuated lipid-induced suppression of glucose oxidation.
Human CPT1A (显示 CPT1A 蛋白), CPT1B (显示 CPT1B 蛋白), CPT2 (显示 CPT2 蛋白), CROT (显示 CROT 蛋白) and CRAT are known to encode active carnitine acyltransferases. Earlier pfam annotations refer to the non-existing compound CARNITATE. In 2000 this has been changed to CARNITINE.
Studies revealed that ablation of CrAT in myeloid lineage cells did not impact glucose homeostasis, insulin (显示 INS 蛋白)-action, adipose tissue leukocytosis, and inflammation when animals were confronted with a variety of metabolic stressors, including high-fat diet, fasting, or LPS (显示 TLR4 蛋白)-induced acute endotoxemia.
Crat-mediated acetyl group buffering is essential for optimal exercise performance.
structural model for L-CPT I (显示 CPT1A 蛋白) (liver CPT I (显示 CPT1A 蛋白)), based on the similarity of this enzyme to the recently crystallized mouse carnitine acetyltransferase
The predicted full length cDNA sequence of the porcine CRAT gene was characterised and a new 5' variant for dog, rat and mouse was proposed.
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene.
, carnitine acetylase
, carnitine acetyltransferase
, carnitine O-acetyltransferase
, Carnitine acetyltransferase
, carnitine acetyl transferase
, Carnitine acetylase