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Human TUBA4A Protein expressed in Wheat germ - ABIN1324116
Ndhlovu, Preuss, Dengjel, Stevanovic, Weiner, Klein: Identification of ?-tubulin as an autoantigen recognized by sera from patients with neuropsychiatric systemic lupus erythematosus. in Brain, behavior, and immunity 2011
The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset.
Its mutations were seen in patients with ALS and frontotemporal dementia.
TUBA4A mutations are not associated with FTD (显示 FTL 蛋白).
In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required.
This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin (显示 TUBB 蛋白) cytoskeleton mediated by binding Tau protein.
TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability
TUBA4A is significantly increased in spermatazoa from men with azoospermia.
The results suggested that cytoskeletal alterations in the amygdala determined by tubulin (显示 TUBB 蛋白) seem to be involved in the pathophysiology of drug addiction
Subunits of alphaB crystallin (显示 CRYAB 蛋白) that exchange dynamically with the alphaB crystallin (显示 CRYAB 蛋白) complex can interact with tubulin (显示 TUBB 蛋白) subunits to regulate the equilibrium between tubulin (显示 TUBB 蛋白) and microtubules.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
tubulin, alpha 1 (testis specific)
, tubulin, alpha 6
, tubulin H2-alpha
, tubulin alpha-1 chain
, tubulin alpha-4A chain
, alpha-tubulin 4
, alpha-tubulin isotype M-alpha-4
, tubulin alpha-4 chain
, tubulin, alpha 4
, alpha-tubulin 1
, tubulin, alpha 1
, tubulin alpha 4a
, tubulin, alpha 4a
, CG8308 gene product from transcript CG8308-RA
, alpha tubulin
, alpha tubulin 67C
, alphaTubulin 67C
, female sterile (3) kavar
, tubulin at 67C
, alpha tubulin1