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Human TUBA4A Protein expressed in Wheat germ - ABIN1324116
Ndhlovu, Preuss, Dengjel, Stevanovic, Weiner, Klein: Identification of ?-tubulin as an autoantigen recognized by sera from patients with neuropsychiatric systemic lupus erythematosus. in Brain, behavior, and immunity 2011
Data indicate a microRNA-1825/TBCB (显示 TBCB 蛋白)/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (显示 IGFALS 蛋白) (fALS) and both sporadic (sALS (显示 CDH23 蛋白)).
The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset.
Its mutations were seen in patients with ALS and frontotemporal dementia.
TUBA4A mutations are not associated with FTD (显示 FTL 蛋白).
In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required.
This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin (显示 TUBB 蛋白) cytoskeleton mediated by binding Tau protein.
TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability
TUBA4A is significantly increased in spermatazoa from men with azoospermia.
The results suggested that cytoskeletal alterations in the amygdala determined by tubulin (显示 TUBB 蛋白) seem to be involved in the pathophysiology of drug addiction
The Kavar(D) dominant female-sterile mutations reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.
Data show that alpha4-tubulin (显示 TUBB 蛋白) is enriched in the long microtubules that embrace the nuclear envelope and suggest that they push apart daughter centrosomes along the nuclear perimeter during the initial cleavage divisions.
Glu426 is involved in stabilization of the microtubule-kinesin complexes when the kinesins are in the most labile, ADP-bound state.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
tubulin, alpha 1 (testis specific)
, tubulin, alpha 6
, tubulin H2-alpha
, tubulin alpha-1 chain
, tubulin alpha-4A chain
, alpha-tubulin 4
, alpha-tubulin isotype M-alpha-4
, tubulin alpha-4 chain
, tubulin, alpha 4
, alpha-tubulin 1
, tubulin, alpha 1
, tubulin alpha 4a
, tubulin, alpha 4a