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All of the patients with a microtubule associated protein 1B (MAP1B) variant had a similar brain abnormality, and at least one of the parents who transmitted the variant to their child was also similarly affected.
MAP1B heavy chain has a unique binding site for a calcium-binding protein (显示 CETN1 蛋白) ALG-2 (显示 PDCD6 蛋白).
These results suggest that a change in the intracellular calcium level plays a role in regulation of the secretory pathway via interaction of ALG-2 (显示 PDCD6 蛋白) with MISSL and MAP1B.
The found of this study suggested that possible roles of MAP1B genes in working memory performance in ADHD patients
KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder.
signal transduction pathways downstream of 5-HT6R (显示 HTR6 蛋白) are regulated by MAP1B, which might play a role in 5-HT6R (显示 HTR6 蛋白)-mediated signaling in the brain.
The the MAP1B-LC1-mediated regulation most likely involves an internalization of the channels via a dynamin (显示 DNM1 蛋白) and clathrin-dependent pathway.
An interaction between MAP1B LC1 and the ubiquitin-conjugating enzyme (显示 Ube2t 蛋白) UBE2L3 (显示 UBE2L3 蛋白).
Localization of MAP1B is altered in amyotrophic lateral sclerosis spinal cords in a transgenic animal model.
Yeast-two-hybrid screening using human LRRK2 kinase domain as bait identified microtubule associated protein 1B (MAP1B) as a LRRK2 interactor.
MAP1B knockout neurons display a decrease in the density of presynaptic and postsynaptic terminals, which involves a reduction in the density of synaptic contacts, and an increased proportion of orphan presynaptic terminals. MAP1B knockout neurons present altered synaptic vesicle fusion events, and a decrease in the density of both synaptic vesicles and dense core vesicles at presynaptic terminals.
MAP1B restricts the access of AMPARs to dendritic spines and the postsynaptic membrane, contributing to downregulating synaptic transmission
MAP1B confers increased stability to tyrosinated and acetylated, but not detyrosinated microtubules.
Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons.
MAP1B is a specific marker protein of the podocyte microtubular cytoskeleton.
Although MAP1A (显示 MAP1A 蛋白) and MAP1B protein levels are not affected in the tulp1 (显示 TULP1 蛋白)-/- retina, they are no longer localized to the outer segment of photoreceptors.
The morphology, phenotype, regional distribution, proliferative dynamics, and stage-specific marker expression of Map5 cells in the rabbit and mouse central nervous system, were characterized.
The MAP1B-Tiam1 (显示 TIAM1 蛋白)-Rac1 relay is essential for spine structural plasticity and removal of AMPA (显示 GRIA3 蛋白) receptors from synapses during long-term depression.
MAP1B interacts directly with EB1 (显示 MAPRE1 蛋白) and EB3 (显示 MAPRE3 蛋白) (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.
MKK7 (显示 MAP2K7 蛋白) is specifically phosphorylated in the neurite shaft which triggers Map1b phosphorylation to regulate microtubule bundling leading to neurite elongation.
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system.
, microtubule associated protein 1B
, Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X))
, microtubule-associated protein 5