Minichromosome Maintenance Deficient 4 抗体
(Minichromosome Maintenance Deficient 4 (MCM4))
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| MCM4 抗体 (Biotin) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MCM4 抗体 (AA 600-800) | 人 | 小鼠 Monoclonal |
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| MCM4 抗体 (AA 600-800) | 人 | 小鼠 Monoclonal |
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| Recombinant MCM4 抗体 (AA 600-800) | 人 | 兔 Monoclonal |
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| Recombinant MCM4 抗体 (AA 600-800) | 人 | 兔 Monoclonal |
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Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 质量等级
- Carrier-free
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- MCM4-3041
- 标记
- unconjugated
- 抗体亚型
- IgG1, kappa
- 抗原表位
- AA 600-800
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- MCM4-3041
- 标记
- unconjugated
- 抗体亚型
- IgG1, kappa
- 抗原表位
- AA 600-800
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- MCM4-13209R
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG, kappa
- 抗原表位
- AA 600-800
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 质量等级
- Carrier-free
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- MCM4-13209R
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG, kappa
- 抗原表位
- AA 600-800
Latest Publications for our Minichromosome Maintenance Deficient 4 抗体
: "Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery." in: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34325-36, (2012) (PubMed).
: "Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle." in: Oncogene, Vol. 29, Issue 26, pp. 3803-14, (2010) (PubMed).
: "Expression, nuclear localization and interactions of human MCM/P1 proteins." in: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 118-25, (1997) (PubMed).
: "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins." in: European journal of biochemistry / FEBS, Vol. 230, Issue 3, pp. 1096-101, (1995) (PubMed).
: "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins." in: Nucleic acids research, Vol. 21, Issue 23, pp. 5289-93, (1994) (PubMed).
: "Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication." in: Nucleic acids research, Vol. 20, Issue 21, pp. 5571-7, (1993) (PubMed).
: "A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication." in: Nucleic acids research, Vol. 21, Issue 11, pp. 2541-7, (1993) (PubMed).
: "Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle." in: Oncogene, Vol. 29, Issue 26, pp. 3803-14, (2010) (PubMed).
: "Expression, nuclear localization and interactions of human MCM/P1 proteins." in: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 118-25, (1997) (PubMed).
: "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins." in: European journal of biochemistry / FEBS, Vol. 230, Issue 3, pp. 1096-101, (1995) (PubMed).
: "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins." in: Nucleic acids research, Vol. 21, Issue 23, pp. 5289-93, (1994) (PubMed).
: "Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication." in: Nucleic acids research, Vol. 20, Issue 21, pp. 5571-7, (1993) (PubMed).
: "A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication." in: Nucleic acids research, Vol. 21, Issue 11, pp. 2541-7, (1993) (PubMed).
Aliases for Minichromosome Maintenance Deficient 4 抗体
minichromosome maintenance complex component 4 L homeolog (mcm4.L) 抗体minichromosome maintenance complex component 4 S homeolog (mcm4.S) 抗体
minichromosome maintenance complex component 4 (MCM4) 抗体
minichromosome maintenance complex component 4 (mcm4) 抗体
minichromosome maintenance complex component 4 (Mcm4) 抗体
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