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These findings indicate that greater synthesis of phosphatidylcholine (显示 SGMS1 蛋白) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
Bhmt(-/-) mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging volume, as well as impaired reference and short-term memories.
BHMT expression is robustly regulated by taurine.
It was concluded that the BHMT pathway is a major route for the elimination of Hcy in mice and that the methionine synthase (显示 MTR 蛋白) pathway has little excess capacity to methylate the Hcy that accumulates when the BHMT pathway is blocked.
mouse blastocysts are unusual in being able to generate AdoMet (显示 MAT1A 蛋白) not only by the ubiquitous folate-dependent mechanism but also from betaine metabolized by BHMT
a role for BHMT in energy homeostasis.
BHMT has an important role in Hcy, choline, and one-carbon homeostasis
The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death.
displays differential expression in a model of liver cirrhosis
, betaine--homocysteine S-methyltransferase 1
, betaine--homocysteine S-methyltransferase
, betaine--homocysteine S-methyltransferase 1-like