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MCAM 产品

(Melanoma Cell Adhesion Molecule (MCAM))

Categories

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

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Featured MCAM Categories

MCAM 抗体

High quality antibodies with extensive validation data.

MCAM ELISA试剂盒

Reliable ELISA kits for a wide range of species.

MCAM 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MCAM 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application FACS, IHC, WB, ELISA
Validations
  • (2)
  • (7)
Cat. No. ABIN1724844
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application FACS, WB, IF, ELISA
Validations
  • (7)
Cat. No. ABIN7147325
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, WB, IF
Validations
  • (7)
Cat. No. ABIN6143621
Quantity 100 μL
Datasheet Datasheet

Recommended MCAM ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (4)
  • (1)
Cat. No. ABIN6960653
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6962587
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6960654
Quantity 96 tests
Datasheet Datasheet

Recommended MCAM 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275297
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275301
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293T Cells
Validations
  • (2)
Cat. No. ABIN2752854
Quantity 2 μg
Datasheet Datasheet

Latest Publications for our MCAM Products

Sun, Ji, Ma, Zhu, Chen, Wang, Qian, Wu, Hu, Huang, Zhang: "Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis." in: Frontiers in immunology, Vol. 11, pp. 1598, (2020) (PubMed).

Tarantini, Valcarcel-Ares, Toth, Yabluchanskiy, Tucsek, Kiss, Hertelendy, Kinter, Ballabh, Süle, Farkas, Baur, Sinclair, Csiszar, Ungvari: "Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice." in: Redox biology, Vol. 24, pp. 101192, (2019) (PubMed).

Zhan, Liu, Wang: "The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." in: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 536-546, (2018) (PubMed).

England, Jiang, Hernandez, Sun, Valdovinos, Ehlerding, Engle, Yang, Huang, Cai: "ImmunoPET Imaging of CD146 in Murine Models of Intrapulmonary Metastasis of Non-Small Cell Lung Cancer." in: Molecular pharmaceutics, Vol. 14, Issue 10, pp. 3239-3247, (2018) (PubMed).

Gao, Zhang, Wang, Liu, He, Liu, Wang, Feng, Yang, Wang, Meng, Yan: "The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis." in: Nature communications, Vol. 8, pp. 15279, (2018) (PubMed).

Wang, Wang, Wu, Qiu, Li, Chu, Huang, Xu, Gong, Li: "Sox10+adult stem cells contribute to biomaterial encapsulation and microvascularization." in: Scientific reports, Vol. 7, pp. 40295, (2017) (PubMed).

De Luca, Carpanese, Rapanotti, Viguria, Forgione, Rotili, Fulci, Iorio, Quintieri, Chimenti, Bianchi, Rosato, Caccuri: "The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis." in: Oncotarget, Vol. 8, Issue 9, pp. 15520-15538, (2017) (PubMed).

Luo, Duan, Qian, Feng, Wu, Wang, Feng, Yang, Qin, Yan: "Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis." in: Cell research, Vol. 27, Issue 3, pp. 352-372, (2017) (PubMed).

Zhang, Chen, Liu, Zhou, Hu, Zhou, Han, Chen: "Exendin-4 promotes proliferation of adipose-derived stem cells through ERK and JNK signaling pathways." in: In vitro cellular & developmental biology. Animal, Vol. 52, Issue 5, pp. 598-606, (2016) (PubMed).

Nodomi, Umeda, Saida, Kinehara, Hamabata, Daifu, Kato, Hiramatsu, Watanabe, Kuwahara, Iehara, Adachi, Konishi, Nakahata, Hosoi, Heike: "CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor." in: Oncogene, Vol. 35, Issue 40, pp. 5317-5327, (2016) (PubMed).

Synonyms and alternative names related to MCAM

melanoma cell adhesion molecule (MCAM), melanoma cell adhesion molecule (Mcam), melanoma cell adhesion molecule b (mcamb), 1-gicerin, AV025631, CD146, cd146, CD149, gicerin, id:ibd3512, mcam, MCAM, MUC18, Muc18, s-endo, s-gicerin

Protein level used designations for MCAM

  • Gicerin
  • S-endo 1 endothelial-associated antigen
  • cell surface glycoprotein MUC18
  • cell surface glycoprotein P1H12
  • melanoma adhesion molecule
  • melanoma-associated antigen A32
  • melanoma-associated antigen MUC18
  • gicerin
  • l-gicerin
  • l-gicerin protein
  • cell adhesion molecule
  • HEMCAM
  • melanoma cell adhesion molecule
  • cell surface glycoprotein MUC18-like
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