Use your antibodies-online credentials, if available.
抗Human MAPK3 抗体:
抗Mouse (Murine) MAPK3 抗体:
抗Rat (Rattus) MAPK3 抗体:
Human Polyclonal MAPK3 Primary Antibody for WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
Show all 6 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
Show all 6 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967700
Ackerley, Grierson, Brownlees, Thornhill, Anderton, Leigh, Shaw, Miller: Glutamate slows axonal transport of neurofilaments in transfected neurons. in The Journal of cell biology 2000
Show all 5 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967701
Aguirre-Ghiso, Liu, Mignatti, Kovalski, Ossowski: Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. in Molecular biology of the cell 2001
Show all 5 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991
Show all 4 Pubmed References
Chicken Polyclonal MAPK3 Primary Antibody for ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. in Biochemistry 1991
Show all 9 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. in The Journal of biological chemistry 1996
Show all 3 Pubmed References
Mouse (Murine) Polyclonal MAPK3 Primary Antibody for IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. in International journal of clinical and experimental pathology 2014
Show all 3 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
Show all 2 Pubmed References
Human Monoclonal MAPK3 Primary Antibody for IP, WB - ABIN967398
Rossomando, Payne, Weber, Sturgill: Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 2 Pubmed References
Apocynin may act as a novel molecular candidate to protect against vascular smooth muscle cell osteogenic switching/vascular calcification through suppressing ERK1/2 (显示 MAPK1/3 抗体) pathway.
GHRH (显示 GHRH 抗体) agonist MR-409 increase phosphorylation of AKT (显示 AKT1 抗体) and ERK1/2 (显示 MAPK1/3 抗体) in dermal fibroblasts.
telomere stability is under direct control of one of the major pro-oncogenic signaling pathways (RAS/RAF (显示 RAF1 抗体)/MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体)) via TRF2 (显示 TERF2 抗体) phosphorylation.
Data suggest that inability of lithium, an anti-manic agent, to regulate circadian rhythms in cells from patient with bipolar disorder reflects reduced ERK1/2 (显示 MAPK1/3 抗体) activity and MAP kinase (显示 MAPK1 抗体) signaling through ELK1 (显示 ELK1 抗体). (ERK (显示 EPHB2 抗体) = extracellular signal-related kinase; ELK1 (显示 ELK1 抗体) = ETS-domain protein (显示 ELK3 抗体) ELK1 (显示 ELK1 抗体))
Report differential expression of EZH2 (显示 EZH2 抗体) protein in small cell and aggressive B-cell non-Hodgkin lymphomas and differential regulation of EZH2 (显示 EZH2 抗体) expression by p-ERK1/2 (显示 MAPK1/3 抗体) and MYC (显示 MYC 抗体) in aggressive B-cell lymphomas.
Data indicate that PD0325901 inhibited extracellular signal-regulated kinases ERK1/2 (显示 MAPK1/3 抗体) phosphorylation.
Findings suggest that ERK1/2 (显示 MAPK1/3 抗体)-mediated Cdk2 (显示 CDK2 抗体)/cyclin A (显示 CCNA2 抗体) signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
Endoplasmic reticulum stress contributes to nefazodone-induced toxicity in HepG2 cells and ERK1/2 (显示 MAPK1/3 抗体) signaling pathway plays an important role.
ERK1 Directly Interacts With JNK1 (显示 MAPK8 抗体) Leading to Regulation of JNK1 (显示 MAPK8 抗体)/c-Jun (显示 JUN 抗体) Activity and Cell Transformation.
egulation of apoptosis was far more sensitive than regulation of proliferation. IGF1 (显示 IGF1 抗体) and insulin (显示 INS 抗体) activated PKB (Akt/PKB (显示 AKT1 抗体)) rapidly and consistently maintained its phosphorylation. Activation of ERK1/2 (显示 MAPK1/3 抗体) was only observed in response to IGF1 (显示 IGF1 抗体).
North American ginseng inhibits myocardial NOX2 (显示 CYBB 抗体)-ERK1/2 (显示 MAPK1/3 抗体)-TNF-alpha (显示 TNF 抗体) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (显示 GFAP 抗体)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB (显示 NFKB1 抗体) activity and ERK1/2 (显示 MAPK1/3 抗体) phosphorylation triggered by microbial infection.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 or Erk2 (显示 MAPK1 抗体) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (显示 CD44 抗体) expression, and increased CD44 (显示 CD44 抗体) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (显示 ICAM1 抗体) and VCAM-1 (显示 VCAM1 抗体) by activating the ERK1/2 (显示 MAPK1/3 抗体) pathway, resulting in the expression of ETB (显示 EDNRB 抗体) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (显示 NFkBP65 抗体), ERK1, ERK2 (显示 MAPK1 抗体) and STAT1 (显示 STAT1 抗体) pathways.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL (显示 KITLG 抗体) signaling.
At low oxLDL levels LOX-1 (显示 OLR1 抗体) activates the protective Oct-1 (显示 POU2F1 抗体)/SIRT1 (显示 SIRT1 抗体) pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 (显示 MAPK1/3 抗体) pathway.
Studies indicate that progesterone receptor (显示 PGR 抗体) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (显示 CXCL9 抗体)-6over) phosphatase and tensin homolog (显示 PTEN 抗体) protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (显示 MAPK1/3 抗体) and its target genes.
ERK1/2 (显示 MAPK1/3 抗体)-Akt1 (显示 AKT1 抗体) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (显示 SH3GL1 抗体) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (显示 MAPK1 抗体) pathway
ERK1 and ERK2 (显示 MAPK1 抗体) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (显示 HSPA1A 抗体) in response to heat stress is dependent on ERK (显示 MAPK1 抗体) activation in Pac2 (显示 PSMG2 抗体) cells.
Data define distinct roles for ERK1 and ERK2 (显示 MAPK1 抗体) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide (显示 NPPC 抗体) and this process is related to the EGFR (显示 EGFR 抗体) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 (显示 EGR1 抗体) via activation of ERK1/2 (显示 MAPK1/3 抗体) and contributes to pulmonary vascular remodeling.
ER Ca(2 (显示 CA2 抗体)+) release enhances eNOS (显示 NOS3 抗体) Ser (显示 SIGLEC1 抗体)-635 phosphorylation and function via ERK1/2 (显示 MAPK1/3 抗体) activation.
Thrombospondin 1 (显示 THBS1 抗体), fibronectin (显示 FN1 抗体), and vitronectin (显示 VTN 抗体) are differentially dependent upon RAS, ERK1/2 (显示 MAPK1/3 抗体), and p38 (显示 MAPK14 抗体) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1 (显示 GAB1 抗体)-ERK1/2 (显示 MAPK1/3 抗体) binding and their nuclear translocation play a crucial role in Egr-1 (显示 EGR1 抗体) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (显示 AKT1 抗体), mTOR (显示 FRAP1 抗体), p70S6K (显示 RPS6KB1 抗体), and ERK1/2 (显示 MAPK1/3 抗体).
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (显示 MAPK1 抗体).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 (显示 MAPK1/3 抗体) dependent.
Results suggest that estrogen receptors and the ERK1/2 (显示 MAPK1/3 抗体) signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (显示 BCL2L11 抗体).
Treatment with ERK (显示 MAPK1 抗体) inhibitors or ERK1/2 (显示 MAPK1/3 抗体) knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 (显示 MAPK1/3 抗体) signaling, has a substantial impact on T cell behavior.
CSF2 (显示 CSF2 抗体) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 (显示 MAPK1/3 抗体) MAPK (显示 MAPK1 抗体)-dependent MTOR (显示 FRAP1 抗体) signal transduction cascades.
PGRN (显示 GRN 抗体) inhibits adipogenesis in porcine preadipocytes partially through ERK (显示 MAPK1 抗体) activation mediated PPARgamma (显示 PPARG 抗体) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (显示 PRKAA1 抗体)/ERK (显示 MAPK1 抗体)/TSC2 (显示 TSC2 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 (显示 MAPK1/3 抗体) and JNK1 (显示 MAPK8 抗体)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 (显示 MAPK1/3 抗体) and p38 MAPK (显示 MAPK14 抗体) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (显示 IGF1 抗体) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (显示 IGF1R 抗体)
The results suggest that the MPK-1 (显示 MAPK1 抗体)/ERK (显示 MAPK1 抗体) regulatory network, including FBF-1 (显示 FBF1 抗体), FBF-2, and LIP-1 (显示 CENPJ 抗体), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (显示 FGFR3 抗体) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (显示 SUV420H1 抗体) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (显示 MAPK1 抗体) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (显示 CDC42 抗体) GTPase (显示 RACGAP1 抗体).
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (显示 MAPK4 抗体), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 (显示 MAPK6 抗体) phosphorylate and destabilize ICE1, which negatively regulates CBF (显示 CEBPZ 抗体) expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (显示 MAPK6 抗体) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (显示 MAPK6 抗体) can both interact with SPOROCYTELESS/NOZZLE (SPL (显示 SGPL1 抗体)) in vitro and in vivo and can phosphorylate the SPL (显示 SGPL1 抗体) protein in vitro.
MKK4 (显示 MAP2K4 抗体), MKK5 (显示 MAP2K5 抗体), MKK7 (显示 MAP2K7 抗体), and MKK9, are responsible for the activation of MPK3 and MPK6 (显示 MAPK6 抗体) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 抗体) signaling through MKK4 (显示 MAP2K4 抗体)/5/7/9-MPK3/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (显示 MAPK6 抗体), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
Results demonstrated the contribution of MPK3 and MPK6 (显示 MAPK6 抗体) to riboflavin-induced resistance.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, mitogen-activated protein kinase 12
, stress-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase