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抗Human MAPK3 抗体:
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Human Polyclonal MAPK3 Primary Antibody for ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
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Human Polyclonal MAPK3 Primary Antibody for WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
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Chicken Polyclonal MAPK3 Primary Antibody for ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. in Biochemistry 1991
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Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991
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Human Polyclonal MAPK3 Primary Antibody for IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
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Human Polyclonal MAPK3 Primary Antibody for WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. in The Journal of biological chemistry 1996
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Mouse (Murine) Polyclonal MAPK3 Primary Antibody for IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. in International journal of clinical and experimental pathology 2014
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Human Polyclonal MAPK3 Primary Antibody for IHC (p), IHC - ABIN152967
Nymoen, Hetland Falkenthal, Holth, Ow, Ivshina, Tropé, Kuznetsov, Staff, Davidson: Expression and clinical role of chemoresponse-associated genes in ovarian serous carcinoma. in Gynecologic oncology 2015
Human Polyclonal MAPK3 Primary Antibody for IHC (p) - ABIN2473492
: [Aleksandr Semenovich Iontov (on his 70th birthday)]. in Arkhiv anatomii, gistologii i émbriologii 1978
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Human Monoclonal MAPK3 Primary Antibody for ICC, FACS - ABIN969277
Karreth, DeNicola, Winter, Tuveson: C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). in Molecular cell 2009
The present study demonstrated that the downregulation of filaggrin (显示 FLG 抗体) in the epidermis by toluene is mediated by ERK1/2 and STAT3 (显示 STAT3 抗体)-dependent pathways.
RASSF7 promotes cell proliferation through activating MEK1 (显示 MAP2K1 抗体)/MEK2 (显示 MAP2K2 抗体)-ERK1/ERK2 (显示 MAPK1 抗体) signaling pathway in hepatocellular carcinoma.
SHP-2 (显示 PTPN11 抗体) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (显示 IL17C 抗体) signaling.
intact keratin filaments are regulators for PKB/Akt (显示 AKT1 抗体) and p44 (显示 GTF2H2 抗体)/42 activity, basal and in response to stretch.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (显示 CRK 抗体)/TRAF-6 (显示 TRAF6 抗体)/ERK (显示 EPHB2 抗体) MAP kinases pathways has been reported.
Integrated ERK1/ERK2 (显示 MAPK1 抗体) response to B (显示 TDO2 抗体)-cell receptor stimulation and SF3B1 (显示 SF3B2 抗体) gene mutations refine prognosis in chronic lymphocytic leukemia.
These findings identified the relationship between ERK1/2 Snitrosylation and phosphorylation.
A cellular threshold for active ERK1/2 levels determines Raf (显示 RAF1 抗体)/MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体)-mediated growth arrest versus death responses.
ERK1/2/p53 (显示 TP53 抗体)/PUMA (显示 BBC3 抗体) signaling axis is related to cisplatin-induced cell death in ovarian cancer cells.
results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha (显示 PPARA 抗体) signaling, inhibiting the TLR4 (显示 TLR4 抗体)-mediated NF-kappaB (显示 NFKB1 抗体) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (显示 TLR4 抗体)/ERK1/2/AP-1 (显示 FOSB 抗体)/STAT3 (显示 STAT3 抗体)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.
M-CSF (显示 CSF1R 抗体)-evoked ERK1/2 activation was decreased, whereas AKT (显示 AKT1 抗体) activation was enhanced in SHP2 (显示 PTPN11 抗体)-deficient BMMs. ERK1/2, via its downstream target RSK2 (显示 RPS6KA3 抗体), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (显示 CSF1R 抗体) receptor at Tyr721 and, consequently, its binding to p85 (显示 ECM1 抗体) subunit of PI3K and PI3K activation.
Low ERK1 Phosphorylation is associated with low liver regeneration.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
In a retinitis pigmentosa mouse model, TrkC (显示 NTRK3 抗体) activity generates phosphorylated Erk (显示 EPHB2 抗体), which upregulates glial TNF-alpha (显示 TNF 抗体), causing selective neuronal death.
A. fumigatus increased PAR-2 expression and elevated disease, PMN infiltration, and proinflammatory cytokine expreERK1 Kinasession through PAR-2, which may be modified by p-ERK1/2.
ERK1 and ERK2 (显示 MAPK1 抗体) play specific roles in beta cells. ERK2 (显示 MAPK1 抗体) cannot always compensate for the lack of ERK1 but the absence of a clear-cut phenotype in Erk1 (-/-) mice shows that ERK1 is dispensable in normal conditions.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (显示 CRK 抗体) Pathways and the Interaction with Cell-Surface-HSP70 (显示 HSP70 抗体).
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
ERK1 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (显示 CRK 抗体) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (显示 MAPK8 抗体) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
MAPK3 role in the oocyte maturation
ERK1/2-Akt1 (显示 AKT1 抗体) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (显示 SH3GL1 抗体) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (显示 MAPK1 抗体) pathway
ERK1 and ERK2 (显示 MAPK1 抗体) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (显示 HSPA1A 抗体) in response to heat stress is dependent on ERK (显示 MAPK1 抗体) activation in Pac2 (显示 PSMG2 抗体) cells.
Data define distinct roles for ERK1 and ERK2 (显示 MAPK1 抗体) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide and this process is related to the EGFR (显示 EGFR 抗体) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (显示 THBS1 抗体), fibronectin (显示 FN1 抗体), and vitronectin (显示 VTN 抗体) are differentially dependent upon RAS, ERK1/2, and p38 (显示 MAPK14 抗体) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (显示 EGR1 抗体) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (显示 MAPK1 抗体).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (显示 BCL2L11 抗体).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (显示 CSF2 抗体) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (显示 MAPK1 抗体)-dependent MTOR (显示 FRAP1 抗体) signal transduction cascades.
PGRN (显示 GRN 抗体) inhibits adipogenesis in porcine preadipocytes partially through ERK (显示 MAPK1 抗体) activation mediated PPARgamma (显示 PPARG 抗体) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (显示 PRKAA1 抗体)/ERK (显示 MAPK1 抗体)/TSC2 (显示 TSC2 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (显示 MAPK8 抗体)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (显示 MAPK14 抗体) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (显示 IGF1 抗体) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (显示 IGF1R 抗体)
The results suggest that the MPK-1 (显示 MAPK1 抗体)/ERK (显示 MAPK1 抗体) regulatory network, including FBF-1 (显示 FBF1 抗体), FBF-2, and LIP-1 (显示 CENPJ 抗体), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (显示 FGFR3 抗体) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (显示 SUV420H1 抗体) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (显示 MAPK1 抗体) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (显示 CDC42 抗体) GTPase (显示 RACGAP1 抗体).
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 and MPK6 (显示 MAPK6 抗体), in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (显示 SPINT1 抗体), HAI2 (显示 SPINT2 抗体), and HAI3 through ABF/AREB transcription factors
Constitutive active-MPK3 plants are more resistant to the hemibiotrophic pathogen Pseudomonas syringae DC3000.
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (显示 MAPK4 抗体), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 (显示 MAPK6 抗体) phosphorylate and destabilize ICE1, which negatively regulates CBF (显示 CEBPZ 抗体) expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (显示 MAPK6 抗体) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (显示 MAPK6 抗体) can both interact with SPOROCYTELESS/NOZZLE (SPL (显示 SGPL1 抗体)) in vitro and in vivo and can phosphorylate the SPL (显示 SGPL1 抗体) protein in vitro.
MKK4 (显示 MAP2K4 抗体), MKK5 (显示 MAP2K5 抗体), MKK7 (显示 MAP2K7 抗体), and MKK9, are responsible for the activation of MPK3 and MPK6 (显示 MAPK6 抗体) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 抗体) signaling through MKK4 (显示 MAP2K4 抗体)/5/7/9-MPK3/6 cascades.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase