Use your antibodies-online credentials, if available.
Human MAPK14 Protein expressed in Baculovirus infected Insect Cells - ABIN2002027
Tamura, Sudo, Senftleben, Dadak, Johnson, Karin: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. in Cell 2000
Show all 4 Pubmed References
Data show that miR (显示 MLXIP 蛋白)-625-3p induces oxaliplatin resistance by abrogating MAP2K6 (显示 MAP2K6 蛋白)-p38 (显示 CRK 蛋白)-regulated apoptosis and cell cycle control networks.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (显示 CRK 蛋白)/TRAF-6 (显示 TRAF6 蛋白)/ERK (显示 EPHB2 蛋白) MAP kinases pathways has been reported.
The cytotoxicity induced by EB1 (显示 MAPRE2 蛋白) gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase..this signaling cascade, however not nuclear factor-kappaB-mediated signaling, induced the expression of cyclooxygenase-2 (显示 PTGS2 蛋白), a key effector of apoptotic death.
Data, including data using network analysis, suggest that angiotensinogen (AGT (显示 AGT 蛋白)), mitogen-activated protein kinase-14 (MAPK14), and prothrombin (显示 F2 蛋白) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
The role of p38 MAP kinase signaling in metastatic clear cell renal cell carcinoma (显示 MOK 蛋白)
Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK inhibitors may be more effective and less toxic if administered at the appropriate time of the day.
Hsp27 (显示 HSPB1 蛋白) and P38MAPK could be used as prognostic factors in Esophageal squamous cell carcinoma.
High p38MAPK expression is associated with non-small cell lung cancer metastasis.
when the cells were treated with SB203580, an inhibitor of the p38 MAPK pathway, the osteogenic effects of Epo (显示 EPO 蛋白) on hPDLSCs and pPDLSCs were attenuated. In conclusion, Epo (显示 EPO 蛋白) may upregulate the bone formation ability of hPDLSCs and pPDLSCs via the p38 MAPK pathways
p38alpha and ATF2 (显示 ATF2 蛋白) expression play a crucial role in the malignant phenotypes of ovarian tumor cells and are a markers of poor prognosis in patients with ovarian serous adenocarcinomas.
P38 and JNK (显示 MAPK8 蛋白) have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Adult zebrafish cardiomyocytes express active p38alpha MAPK (显示 MAPK1 蛋白), which is switched off upon entry into mitosis.
Dkk3r regulates p38a phosphorylation to maintain Smad4 (显示 SMAD4 蛋白) stability, in turn enabling the Smad2 (显示 SMAD2 蛋白).Smad3a.Smad4 complex to form and activate the myf5 (显示 MYF5 蛋白) promoter.
results suggest that ET-1 (显示 EDN1 蛋白)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (显示 NOX1 蛋白)-PKCalpha (显示 PKCa 蛋白)-p(38)MAPK (显示 MAPK1 蛋白) and NFkappaB-MT1MMP (显示 MMP14 蛋白) signaling pathways along with a marked decrease in TIMP-2 (显示 TIMP2 蛋白) expression in the cells
cross-talk between p(38)MAPK (显示 MAPK1 蛋白) and Gialpha play a pivotal role for full activation of cPLA2 (显示 PLA2G4A 蛋白) during ET-1 (显示 EDN1 蛋白) stimulation of pulmonary artery smooth muscle cells.
MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
p38 phosphorylation and MMP13 (显示 MMP13 蛋白) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data suggest that the p38 and JNK (显示 MAPK8 蛋白) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (显示 SLC12A1 蛋白) involves activation of p38 and JNK (显示 MAPK8 蛋白) MAPKs
These data suggest a differential requirement of JNK1 (显示 MAPK8 蛋白) and p38 MAPK in TNF (显示 TNF 蛋白) regulation of E2F1 (显示 E2F1 蛋白). Targeted inactivation of JNK1 (显示 MAPK8 蛋白) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (显示 TNF 蛋白)-mediated EC dysfunction.
p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.
These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK (显示 JAK3 蛋白) signalling in a Drosophila model of Myeloproliferative neoplasms.
ROS (显示 ROS1 蛋白)/JNK (显示 MAPK8 蛋白)/p38/Upd (显示 UROD 蛋白) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
Data show that the genetic interaction between p38b MAPK (显示 MAPK1 蛋白) and Rack1 (显示 GNB2L1 蛋白) controls muscle aggregate formation, locomotor function, and longevity.
The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (显示 MAPK1 蛋白) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.
The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.
p38b MAPK (显示 MAPK1 蛋白) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.
the D-p38b gene is regulated by the DREF (显示 ZBED1 蛋白) pathway and DREF (显示 ZBED1 蛋白) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (显示 NFS1 蛋白) and progenitors
we have identified novel interaction between p38 MAPK and Runx2 (显示 RUNX2 蛋白) enhances Runx2 (显示 RUNX2 蛋白) transactivity, thus promoting vascular smooth muscle cells calcification
p38alpha MAPK (显示 MAPK1 蛋白) maintains the expression of antioxidant genes in liver of young animals via NF-kappaBeta (显示 NFKB1 蛋白) under basal conditions, whereas its long-term deficiency triggers compensatory up-regulation of antioxidant enzymes through NF-kappaBeta (显示 NFKB1 蛋白).
the present findings suggested that artesunate may exert protective effects against cerebral ischemia/reperfusion injury through the suppression of oxidative and inflammatory processes, via activating Nrf2 (显示 NFE2L2 蛋白) and downregulating ROSdependent p38 MAPK in mice.
Results show that the p38 MAPK signaling pathway could regulate mitochondria Abeta (显示 APP 蛋白) internalization by manipulating the expression of alpha7nAChR. Pretreatment of alpha7nAChR agonist could attenuate these biochemical changes which are tightly associated with Abeta1-42 induced apoptosis. Suggesting there is an endogenous, previously unrecognized cholinergic mechanism to control mitochondria functions and their apoptotic ...
Prdx1 (显示 PRDX1 蛋白) knockout can aggravate the oxidative stress and lung injury by increasing the level of Reactive Oxygen Species (ROS (显示 ROS1 蛋白)), and also activate P38 (显示 CRK 蛋白)/JNK (显示 MAPK8 蛋白) signaling pathway.
P38 (显示 CRK 蛋白) kinase role in the inflammatory pain.CXCL13, upregulated by peripheral inflammation, acts on CXCR5 (显示 CXCR5 蛋白) on dorsal root ganglia neurons and activates p38 (显示 CRK 蛋白), which increases Nav1.8 (显示 SCN10A 蛋白) current density and further contributes to the maintenance of inflammatory pain.
these findings indicate that BMS309403 reduces fatty acid-induced ER stress-associated inflammation in skeletal muscle by reducing p38 MAPK activation.
report insulin-like growth factor-II binding protein 1 (IGF2BP1 (显示 B4GALNT2 蛋白)) as a novel interacting partner of p38 MAPK.
These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2 (显示 ACE2 蛋白)-Ang (显示 ANG 蛋白)(17)-Mas (显示 MAS1 蛋白) axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB (显示 NFKB1 蛋白) signaling pathway
results suggest that c-Jun (显示 JUN 蛋白), p38 MAPK, PIK3CA (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白), and GSK3 signaling involved in the effect of miR (显示 MLXIP 蛋白)-203 on the proliferation of hepatocellular carcinoma cells.
cytochrome c (显示 CYCS 蛋白) microinjection induces p38 phosphorylation through caspase-3 (显示 CASP3 蛋白) activation, and caspase (显示 CASP3 蛋白) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock
p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.
p38 Mitogen-activated protein kinase (MAPK (显示 MAPK1 蛋白)) is essential for drug-induced COX-2 (显示 PTGS2 蛋白) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.
These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.
Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.
The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1 (显示 SIRT1 蛋白)/Nrf2 (显示 NFE2L2 蛋白) and p38 MAPK pathways.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (显示 IL10 蛋白) production through p38 MAPK activation.
JNK (显示 MAPK8 蛋白) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
These findings suggest that the TQ-induced production of ROS (显示 ROS1 蛋白) causes dedifferentiation through the ERK (显示 MAPK1 蛋白) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.
These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (显示 NFKB1 蛋白), p53 (显示 TP53 蛋白) and caspase-3 (显示 CASP3 蛋白) activation.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Csaids binding protein
, MAP kinase 14
, MAP kinase 2
, MAP kinase Mxi2
, MAP kinase p38 alpha
, MAPK 14
, MAX-interacting protein 2
, cytokine suppressive anti-inflammatory drug binding protein
, cytokine-supressive anti-inflammatory drug binding protein
, mitogen-activated protein kinase 14
, mitogen-activated protein kinase 14A
, mitogen-activated protein kinase p38 alpha
, p38 MAP kinase
, p38 mitogen activated protein kinase
, p38alpha Exip
, reactive kinase
, stress-activated protein kinase 2A
, MAP kinase 14B
, MAP kinase p38b
, MAPK 14B
, mitogen-activated protein kinase 14B
, mitogen-activated protein kinase p38b
, p38 mitogen-activated protein kinase
, stress-activated p38b MAP kinase
, cytokine suppressive anti-inflammatory drug binding protein 1
, mitogen activated protein kinase 14
, p38 MAP kinase alpha
, p38 MAPK
, p38 alpha
, tRNA synthetase cofactor p38
, MAPK p38
, Mitogen-activated protein kinase 2
, mitogen-activated Mitogen-activated protein kinase 2
, p38 mitogen-activated kinase
, CSAIDS-binding protein 1
, stress-activated protein kinase 2a
, MAP kinase 14A
, MAP kinase p38a
, MAPK 14A
, Mitogen-activated protein kinase p38a
, mitogen-activated protein kinase p38a