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抗Human MAP2K6 抗体:
抗Rat (Rattus) MAP2K6 抗体:
抗Mouse (Murine) MAP2K6 抗体:
Human Monoclonal MAP2K6 Primary Antibody for IHC, ELISA - ABIN969270
Arning, Monté, Hansen, Wieczorek, Jagiello, Akkad, Andrich, Kraus, Saft, Epplen: ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. in Journal of molecular medicine (Berlin, Germany) 2008
Human MAP2K6 Primary Antibody for IHC - ABIN966580
Wang, Chen, Liao, Deng, Zhou, Huang, Sun: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. in Molecular and cellular biology 2002
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Human Polyclonal MAP2K6 Primary Antibody for IHC - ABIN966581
Raingeaud, Whitmarsh, Barrett, Dérijard, Davis: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. in Molecular and cellular biology 1996
Show all 2 Pubmed References
Human Polyclonal MAP2K6 Primary Antibody for IF (p), IHC (p) - ABIN681568
Shi, Zhan, Zhao, Wang, Ma: Effects of Fluoride on the Expression of p38MAPK Signaling Pathway-Related Genes and Proteins in Spleen Lymphocytes of Mice. in Biological trace element research 2016
acts as a repressor of UCP1 (显示 UCP1 抗体) expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure
MEK2 (显示 MAP2K2 抗体) was essential for the phosphorylation of MKK3 (显示 MAP2K3 抗体)/MKK6 and p38 MAPK (显示 MAPK14 抗体) that directly impacted on cyclin D1 (显示 CCND1 抗体) expression.
Data indicate that mitogen-activated protein kinase kinase 6 (MKK6) levels were substantially higher in monocytes than in neutrophils.
Data show significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls.
uncover a new mechanism of deactivation of MKK6-p38 (显示 CRK 抗体) and substantiate a novel regulatory role of FBXO31 (显示 FBXO5 抗体) in stress response
Serine phosphorylation of p66shc (显示 SHC1 抗体) is carried out by active MKK6. beta-Amyloid-induced ROS (显示 ROS1 抗体) production and apoptosis increased in the presence of MKK6 and p66shc (显示 SHC1 抗体), which directly associate.
The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1 (显示 MAP3K5 抗体), and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A resolution and represents an auto-inhibition state of MAP2K6
Data suggest aberrant MAP2K protein (MKK3 (显示 MAP2K3 抗体), MKK4 (显示 MAP2K4 抗体), MKK6, and MKK7 (显示 MAP2K7 抗体)) expression indicates that altered cellular signal transduction mediated via JNK (显示 MAPK8 抗体) and p38 (显示 CRK 抗体) may be common in bladder cancer.
the balance between MKK6 and MKK3 (显示 MAP2K3 抗体) mediates p38 MAPK (显示 MAPK14 抗体) associated resistance to cisplatin in NSCLC
MAP2K6 functions in mouse testis determination, via positive effects on Sry (显示 SRY 抗体), and a minor role for MAP2K3 (显示 MAP2K3 抗体).
MKK3 (显示 MAP2K3 抗体) and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 (显示 MAP2K3 抗体) directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
Activation of distinct p38MAPK (显示 MAPK14 抗体) isoforms is regulated by the selective and synchronized action of two kinases, MKK3 (显示 MAP2K3 抗体) and MKK6, in response to cell stress.
MKK6 is downreglated in peripheral CD4 (显示 CD4 抗体)(+)T cells
p38alpha (显示 MAPK14 抗体) can negatively regulate the stability of the MKK6 mRNA and thus control the steady-state concentration of one of its upstream activators
Involvement of MKK6 in apoptotic cell death in thymocytes.
MKK6 is one of three different protein kinases which activate p38 MAPK (显示 MAPK14 抗体) in vitro.
MKK3 (显示 MAP2K3 抗体) and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses
increased activity of Sox9 (显示 SOX9 抗体) accounts at least in part for the phenotype caused by constitutive activation of MKK6 in chondrocytes
Arabidopsis MPK4 (显示 MAPK4 抗体) can interact with and be phosphorylated by the cytokinesis-related MAP kinase (显示 MAPK1 抗体) kinase, AtMKK6.
AtMKK6-AtMPK13 (显示 MAPK1/3 抗体) module positively regulates lateral root formation.
Plants with mutations in the MKK6/ANQ gene exhibit severe defects in cytokinesis.
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
MAPK/ERK kinase 6
, MAPKK 6
, MEK 6
, SAPK kinase 3
, dual specificity mitogen-activated protein kinase kinase 6
, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
, stress-activated protein kinase kinase 3
, MAP kinase kinase 6
, mitogen activated protein kinase kinase 6
, protein kinase, mitogen activated, kinase 6
, mitogen-activated protein kinase kinase 3