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MAP2K6 抗体

MAP2K6 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
产品编号 ABIN7268643
发货至: 中国
  • 抗原 See all MAP2K6 抗体
    MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
    适用
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    宿主
    • 87
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    克隆类型
    • 90
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    单克隆
    标记
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    This MAP2K6 antibody is un-conjugated
    应用范围
    • 82
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    Western Blotting (WB)
    原理
    MEK3/MEK6 Rabbit mAb
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Monoclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthesized peptide derived from human MEK3/MEK6
    亚型
    IgG
    Top Product
    Discover our top product MAP2K6 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
    别名
    MAP2K3/MAP2K6 (MAP2K6 产品)
    别名
    MAPKK6 antibody, MEK6 antibody, MKK6 antibody, PRKMK6 antibody, SAPKK-3 antibody, SAPKK3 antibody, Mkk6 antibody, Prkmk6 antibody, MKK3 antibody, map2k3 antibody, zMKK3 antibody, map2k6 antibody, mitogen-activated protein kinase kinase 6 antibody, mitogen-activated protein kinase kinase 6 L homeolog antibody, MAP2K6 antibody, Map2k6 antibody, map2k6 antibody, map2k6.L antibody
    背景
    The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008],MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2,Protein phosphorylation,MAP2K3/MAP2K6
    分子量
    39,37kDa
    基因ID
    5606, 5608
    UniProt
    P46734, P52564
    途径
    MAPK Pathway, TLR signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
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