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Human Polyclonal MORC3 Primary Antibody for ICC, IF - ABIN4335296
Sloan, Tatham, Groslambert, Glass, Orr, Hay, Everett: Analysis of the SUMO2 Proteome during HSV-1 Infection. in PLoS pathogens 2015
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Human Polyclonal MORC3 Primary Antibody for WB - ABIN525221
Ceribelli, Isailovic, De Santis, Generali, Fredi, Cavazzana, Franceschini, Cantarini, Satoh, Selmi: Myositis-specific autoantibodies and their association with malignancy in Italian patients with polymyositis and dermatomyositis. in Clinical rheumatology 2016
Cow (Bovine) Polyclonal MORC3 Primary Antibody for WB - ABIN2782386
Takahashi, Yoshida, Murakami, Kawata, Ishizaki, Tanaka-Okamoto, Miyoshi, Zinn, Shime, Inoue: Dynamic regulation of p53 subnuclear localization and senescence by MORC3. in Molecular biology of the cell 2007
Human Polyclonal MORC3 Primary Antibody for WB - ABIN1881548
Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: Initial characterization of the human central proteome. in BMC systems biology 2011
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MORC3 colocalizes with PML (显示 PML 抗体) by a two-step molecular mechanism.
MORC3 (microrchidia3)-ATPase (显示 DNAH8 抗体) activated p53 (显示 TP53 抗体) and induced cellular senescence in normal fibroblasts but not p53 (显示 TP53 抗体)-/- fibroblasts
our studies provide a molecular framework detailing MORC3 functions and suggest that its modulation may contribute to human disease.
Dermatomyositis patients with anti-NXP-2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease.
MORC3 has antiviral activity during herpes simplex virus 1 and human cytomegalovirus infections.
Downregulation of NXP2/MORC3 by use of two independent short hairpin RNAs reduced virus titers in low-multiplicity infections. Analysis of viral RNA in high-multiplicity infections showed a reduction of viral RNA and mRNA after NXP2/MORC3 downregulation.
Case Report: Pemphigus foliaceus (显示 DSG1 抗体) associated with anti-NXP2 autoantibody-positive amyopathic dermatomyositis.
These studies demonstrate that anti-NXP-2 and anti-TIF (显示 TYRO3 抗体)-1gamma antibodies are frequent DM specificities (found in 55% of patients) and are present in most patients with cancer-associated dermatomhyositis.
An anti-MJ antibody that recognizes NXP-2 was found to be a useful biomarker in dermatomyositis-polymyositis patients.
Anti-NXP2 Ab may be associated with adult idiopathic inflammatory myopathies with malignancy.
When tethered to a promoter by fusion to Gal4, NXP-2 repressed transcription, consistent with a role for NXP-2 in SUMO-mediated repression
This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.
zinc finger, CW-type with coiled-coil domain 3
, MORC family CW-type zinc finger protein 3
, nuclear matrix protein NXP2
, zinc finger CW-type coiled-coil domain protein 3
, zinc finger, CW type with coiled-coil domain 3
, microrchidia 3