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High G3BP2 levels worsened prognosis in breast cancer. Cell lines with lower G3BP2 levels required substantially higher cell numbers to form tumors in NOD/SCID (显示 PRKDC 蛋白) mice. G3BP2 regulates SART3 (显示 SART3 蛋白), Nanog (显示 NANOG 蛋白), and Oct-4 (显示 POU5F1 蛋白) expression levels and may be responsible for the maintenance of subpopulations of breast cancer cells with long-term proliferative properties.G3BP2 is important in breast tumor initiation.
Translocation of p53 (显示 TP53 蛋白) is regulated by androgen-dependent sumoylation mediated by the G3BP2-interacting SUMO-E3 ligase (显示 PIAS1 蛋白), RanBP2. G3BP2 knockdown results in reduced tumor growth and increased nuclear p53 (显示 TP53 蛋白) accumulation in mouse xenograft models of prostate cancer with or without long-term androgen deprivation.
G3BP (显示 G3BP1 蛋白) mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10 (显示 USP10 蛋白).
FGDF peptide binds and changes conformation of the protruding N-terminal residues by providing hydrophobic interactions to a symmetry related molecule that facilitated crystallization of the G3BP2 isoform.
G3BP1 (显示 G3BP1 蛋白), G3BP2 and CAPRIN1 are required for translation of interferon (显示 IFNA 蛋白) stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
Reveal a TWIST1 (显示 TWIST1 蛋白)-G3BP2 mechanotransduction pathway that responds to biomechanical signals from the tumour microenvironment to drive EMT (显示 ITK 蛋白), invasion and metastasis.
Stress granule components G3BP1 (显示 G3BP1 蛋白) and G3BP2 play a proviral role early in Chikungunya virus replication.
both G3BP1 (显示 G3BP1 蛋白) and G3BP2 play a role in the formation of SGs (显示 FBN1 蛋白) in various human cells and thereby recovery from these cellular stresses.
Data show that the nsP3 (显示 SH2D3C 蛋白)/G3BP (显示 G3BP1 蛋白) interaction also blocks stress granules (SGs (显示 FBN1 蛋白)) induced by other stresses than virus infection.
first evidence of direct interactions between PKCalpha (显示 PKCa 蛋白) and G3BP2 and that PKCalpha (显示 PKCa 蛋白) can phosphorylate G3BP2.
Wnt3a (显示 WNT3A 蛋白)-stimulated LRP6 (显示 LRP6 蛋白) phosphorylation is dependent upon arginine methylation of G3BP2.
Probable scaffold protein that may be involved in mRNA transport (Potential).
ras GTPase-activating protein-binding protein 2
, Ras-GTPase activating protein SH3 domain-binding protein 2
, Ras GTPase-activating protein-binding protein 2
, GTPase activating protein (SH3 domain) binding protein 2
, GAP SH3 domain-binding protein 2
, Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2
, Ras-GTPase-activating protein (GAP<120>) SH3-domain binding protein 2