MAP3K12 抗体
(Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010].
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Latest Publications for our MAP3K12 抗体
: "Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons." in: Neuron, Vol. 94, Issue 6, pp. 1142-1154.e6, (2017) (PubMed).: "MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 36, Issue 2, pp. 712-26, (2015) (PubMed).
: "ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 32, pp. 10729-42, (2014) (PubMed).
: "The DLK gene is a transcriptional target of PPAR?." in: The Biochemical journal, Vol. 438, Issue 1, pp. 93-101, (2011) (PubMed).
: "The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12732-41, (2005) (PubMed).
: "Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo." in: Gene expression patterns : GEP, Vol. 5, Issue 4, pp. 517-23, (2005) (PubMed).
: "SP3 acts as a positive regulator on the core promoter of human ZPK gene." in: Biochemical and biophysical research communications, Vol. 313, Issue 3, pp. 612-8, (2003) (PubMed).
: "MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo." in: Development (Cambridge, England), Vol. 129, Issue 19, pp. 4483-95, (2002) (PubMed).
: "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21247-54, (2000) (PubMed).
: "Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 10, pp. 1287-96, (1999) (PubMed).
Aliases for MAP3K12 抗体
mitogen-activated protein kinase kinase kinase 12 (MAP3K12) 抗体mitogen activated protein kinase kinase kinase 12 (Map3k12) 抗体
mitogen-activated protein kinase kinase kinase 12 (Map3k12) 抗体
mitogen-activated protein kinase kinase kinase 12 (map3k12) 抗体
mitogen-activated protein kinase kinase kinase 12 S homeolog (map3k12.S) 抗体
mitogen-activated protein kinase kinase kinase 12 L homeolog (map3k12.L) 抗体
DKFZp459K2433 抗体
DLK 抗体
dlk 抗体
map3k12 抗体
map3k12-a 抗体
map3k12-b 抗体
map3k12a 抗体
map3k12b 抗体
MEKK12 抗体
mekk12 抗体
MGC151798 抗体
MUK 抗体
muk 抗体
PK 抗体
zgc:77370 抗体
ZPK 抗体
Zpk 抗体
zpk 抗体
ZPKP1 抗体
zpkp1 抗体
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