MAP3K12 产品
(Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))
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This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010].
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Featured MAP3K12 Categories
MAP3K12 抗体
High quality antibodies with extensive validation data.
MAP3K12 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP3K12 抗体
Product
Reactivity
Application
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Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7235601
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (2)
- (2)
Cat. No.
ABIN391319
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (3)
Cat. No.
ABIN3031847
Quantity
0.4 mL
Datasheet
Datasheet
Recommended MAP3K12 蛋白
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Source
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Cat. No.
Quantity
Datasheet
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Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569690
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3083503
Quantity
1 mg
Datasheet
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Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
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Cat. No.
ABIN3122717
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MAP3K12 Products
: "Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons." in: Neuron, Vol. 94, Issue 6, pp. 1142-1154.e6, (2017) (PubMed).: "MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 36, Issue 2, pp. 712-26, (2015) (PubMed).
: "ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 32, pp. 10729-42, (2014) (PubMed).
: "The DLK gene is a transcriptional target of PPAR?." in: The Biochemical journal, Vol. 438, Issue 1, pp. 93-101, (2011) (PubMed).
: "The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12732-41, (2005) (PubMed).
: "Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo." in: Gene expression patterns : GEP, Vol. 5, Issue 4, pp. 517-23, (2005) (PubMed).
: "SP3 acts as a positive regulator on the core promoter of human ZPK gene." in: Biochemical and biophysical research communications, Vol. 313, Issue 3, pp. 612-8, (2003) (PubMed).
: "MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo." in: Development (Cambridge, England), Vol. 129, Issue 19, pp. 4483-95, (2002) (PubMed).
: "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21247-54, (2000) (PubMed).
: "Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 10, pp. 1287-96, (1999) (PubMed).
Synonyms and alternative names related to MAP3K12
mitogen-activated protein kinase kinase kinase 12 (MAP3K12), mitogen activated protein kinase kinase kinase 12 (Map3k12), mitogen-activated protein kinase kinase kinase 12 (Map3k12), mitogen-activated protein kinase kinase kinase 12 (map3k12), mitogen-activated protein kinase kinase kinase 12 S homeolog (map3k12.S), mitogen-activated protein kinase kinase kinase 12 L homeolog (map3k12.L), DKFZp459K2433, DLK, dlk, map3k12, map3k12-a, map3k12-b, map3k12a, map3k12b, MEKK12, mekk12, MGC151798, MUK, muk, PK, zgc:77370, ZPK, Zpk, zpk, ZPKP1, zpkp1Protein level used designations for MAP3K12
- MAPK-upstream kinase
- dual leucine zipper bearing kinase
- dual leucine zipper kinase DLK
- leucine zipper protein kinase
- mixed lineage kinase
- protein kinase MUK
- Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase)
- Zipper (leucine) protein kinase
- dual leucine zipper kinase
- leucine-zipper protein kinase
- mitogen-activated protein kinase kinase kinase 12
- mitogen activated protein kinase kinase kinase 12
- zipper (leucine) protein kinase
- mitogen activated protein kinase kinase kinase 12 type A
- mitogen activated protein kinase kinase kinase 12 type B
- mitogen-activated protein kinase kinase kinase 12 L homeolog
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