MAP3K9 产品
(Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))
Categories
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
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Featured MAP3K9 Categories
Recommended MAP3K9 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (4)
Cat. No.
ABIN872294
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7160061
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN543253
Quantity
400 μL
Datasheet
Datasheet
Recommended MAP3K9 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569769
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310241
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3093690
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MAP3K9 Products
: "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." in: Hearing research, Vol. 270, Issue 1-2, pp. 21-7, (2011) (PubMed).: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).
: "Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation." in: BMC genomics, Vol. 10, pp. 67, (2009) (PubMed).
: "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop." in: Biochemistry, Vol. 43, Issue 51, pp. 16348-55, (2004) (PubMed).
: "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47922-7, (2003) (PubMed).
: "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis." in: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4713-24, (2001) (PubMed).
Synonyms and alternative names related to MAP3K9
mitogen-activated protein kinase kinase kinase 9 (MAP3K9), mitogen-activated protein kinase kinase kinase 9 (Map3k9), E130314H24Rik, MEKK9, MLK1, Mlk1, PRKE1, Prke1, RGD1562149Protein level used designations for MAP3K9
- mixed lineage kinase 1 (tyr and ser/thr specificity)
- mitogen activated protein kinase kinase kinase 9
- mixed-lineage kinase 1
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