电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

FcRn ELISA 试剂盒

FcRn 适用: 小鼠 AA 22-297 Colorimetric Sandwich ELISA
产品编号 ABIN5510641
发货至: 中国
  • 抗原 See all FcRn ELISA试剂盒
    FcRn (IgG receptor FcRn (FcRn))
    抗原表位
    AA 22-297
    适用
    • 3
    • 2
    • 1
    小鼠
    检测方法
    Colorimetric
    实验类型
    Sandwich ELISA
    应用范围
    ELISA
    原理
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse FCRN/FCGRT
    品牌
    PicoKine™
    Analytical Method
    Quantitative
    特异性
    Expression system for standard: NSO
    Immunogen sequence: S22-S297
    交叉反应 (详细)
    There is no detectable cross-reactivity with other relevant proteins.
    产品特性

    Tissue Specificity: Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.

    Featured
    Discover our best selling FcRn ELISA Kit
    Top Product
    Discover our top product FcRn ELISA Kit
  • 板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    有效期
    12 months
  • 抗原 See all FcRn ELISA试剂盒
    FcRn (IgG receptor FcRn (FcRn))
    别名
    Fcgrt (FcRn 产品)
    别名
    FCRN ELISA Kit, alpha-chain ELISA Kit, FcRn ELISA Kit, Fc fragment of IgG receptor and transporter ELISA Kit, Fc receptor, IgG, alpha chain transporter ELISA Kit, FCGRT ELISA Kit, Fcgrt ELISA Kit
    背景

    Protein Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.

    Background: The neonatal Fc receptor (FcRn), also known as the Brambell receptor, is a protein that in humans is encoded by the FCGRT gene. The neonatal Fc receptor is an Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. It was first discovered in rodents as a unique receptor capable of transporting IgG from mother's milk across the epithelium of newborn rodent's gut into the newborn's bloodstream. Further studies revealed a similar receptor in humans, leading to the naming as a neonatal Fc receptor. In humans, however, it is found in the placenta to help facilitate transport of mother's IgG to the growing fetus and it has also been shown to play a role in monitoring IgG turnover. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine,TNF-i±, and down-regulated by IFN-i³.

    Synonyms: IgG receptor FcRn large subunit p51,FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor,Fcgrt,Fcrn,

    Full Gene Name: IgG receptor FcRn large subunit p51

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein.
    UniProt
    Q61559
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
You are here:
客服