IGF1 ELISA 试剂盒 (Insulin-Like Growth Factor 1)

Details for Product IGF1 ELISA Kit No. ABIN5510545, 供应商: Log in to see
抗原
  • IGF-I
  • IGF1A
  • IGFI
  • C730016P09Rik
  • Igf-1
  • Igf-I
  • Npt2B
  • IGF-1
  • IGFIA
  • IGF-IB
  • igf1
  • IGF-1L
  • IGF-1a
  • IGF1
  • igf-1
  • igf1-A
  • igf1.S
  • xigf1
  • insulin like growth factor 1
  • insulin-like growth factor 1
  • insulin-like growth factor I
  • insulin like growth factor 1 L homeolog
  • IGF1
  • Igf1
  • LOC100136741
  • igf1
  • LOC678666
  • igf1.L
抗原表位
AA 49-118
适用

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实验类型
Sandwich ELISA
应用范围
ELISA
选项
Supplier
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Supplier Product No.
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原理 Sandwich High Sensitivity ELISA kit for Quantitative Detection of Bovine IGF-1
品牌 PicoKine™
Analytical Method Quantitative
检测方法 Colorimetric
特异性 Expression system for standard: E.coli
Immunogen sequence: G49-A118
交叉反应 (详细) There is no detectable cross-reactivity with IGF-2.
产品特性

Sequence similarities: Belongs to the insulin family.

Plasmids, Primers & others Plasmids, Primers & others IGF1 products on genomics-online (e.g. as negative or positive controls)
别名 IGF1 (IGF1 ELISA Kit 摘要)
背景

Protein Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. .

Background: Insulin-like growth factor 1(IGF-1) that was once called somatomedin C, is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. Bovine IGF1 is a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges, with a calculated molecular mass of 7.6 kD.1 The IGF1 gene, mapped on 12q22-q24. contains 5 exons. Exons 1-4 encode the 195-amino acid precursor(IGF1B), and exons 1, 2, 3, and 5 encode the 153-residue peptide(IGF1A). The structure of IGF1 resembles that of IGF2. And the IGF1 and IGF2 genes have complex structures with multiple promoters. The expression of both genes is regulated at the levels of transcription, RNA processing, and translation. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Moreover, approximately 98 % of IGF-1 is always bound to one of 6 binding proteins(IGF-BP). Furthermore, IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

Synonyms: Insulin-like growth factor I,IGF-I,Mechano growth factor,MGF,Somatomedin-C,IGF1,IBP1,

Full Gene Name: Insulin-like growth factor I

Cellular Localisation: Secreted.
UniProt P05019
途径 RTK signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation
板类型 Pre-coated
限制 仅限研究用
储存条件 4 °C,-20 °C
储存方法 Store at 4 °C for 6 months, at -20 °C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
有效期 12 months
厂商提供的图像
ELISA image for Insulin-Like Growth Factor 1 (IGF1) ELISA Kit (ABIN5510545) Bovine IGF-1 PicoKine ELISA Kit standard curve
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