FNDC5
(Fibronectin Type III Domain Containing 5 (FNDC5))
适用
人, 小鼠, 大鼠, 猴
检测方法
Colorimetric
实验类型
Competition ELISA
检测范围
0.001-5 μg/mL
最低检测浓度
0.001 μg/mL
应用范围
ELISA
样品类型
Cell Culture Supernatant, Plasma, Serum
Analytical Method
Quantitative
特异性
Detects human irisin. It should also work in mouse, rat and monkey biological samples.
交叉反应
人, 猴, 小鼠, 大鼠
无交叉反应
小鼠
交叉反应 (详细)
Does not cross-react with FNDC4, human adiponectin, human Nampt, human RBP4, human clusterin, human leptin, human vaspin, human GPX3, human resistin, human ACE2, human lipocalin-2, human ANGPTL3, human ANGPTL6, human DNER, human DLK1, human calreticulin, human IL-33, mouse Nampt, mouse clusterin, mouse vaspin or mouse resistin.
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.