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KEAP1 产品

(Kelch-Like ECH-Associated Protein 1 (KEAP1))
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured KEAP1 Categories

KEAP1 抗体

High quality antibodies with extensive validation data.

KEAP1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

KEAP1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KEAP1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC, IHC (p), FACS
Validations
  • (8)
Cat. No. ABIN1499016
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, FACS, ICC
Validations
  • (2)
  • (5)
Cat. No. ABIN1098137
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS
Validations
  • (2)
  • (5)
Cat. No. ABIN1098141
Quantity 0.1 mg
Datasheet Datasheet

Recommended KEAP1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6957270
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968103
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975693
Quantity 96 tests
Datasheet Datasheet

Recommended KEAP1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1308530
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (21)
  • (1)
Cat. No. ABIN2724103
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123669
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our KEAP1 Products

Jastrząb, Gęgotek, Skrzydlewska: "Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation." in: Cells, Vol. 8, Issue 8, (2020) (PubMed).

Han, Shi, Du, Shi, Zhang, Zheng, Xu, Jiang: "Schisandrin C targets Keap1 and attenuates oxidative stress by activating Nrf2 pathway in Ang II-challenged vascular endothelium." in: Phytotherapy research : PTR, Vol. 33, Issue 3, pp. 779-790, (2019) (PubMed).

Xiang, Ye, Huang, Yu, Chen, Deng, Zhang, Lou, Zhang, Shi, Chen, Zhou: "Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway." in: Oxidative medicine and cellular longevity, Vol. 2018, pp. 2360427, (2018) (PubMed).

Kabel, Alzahrani, Bawazir, Khawtani, Arab: "Targeting the proinflammatory cytokines, oxidative stress, apoptosis and TGF-β1/STAT-3 signaling by irbesartan to ameliorate doxorubicin-induced hepatotoxicity." in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 24, Issue 8, pp. 623-631, (2018) (PubMed).

Kabel, Abd Elmaaboud, Atef, Baali: "Ameliorative potential of linagliptin and/or calcipotriol on bleomycin-induced lung fibrosis: In vivo and in vitro study." in: Environmental toxicology and pharmacology, Vol. 50, pp. 216-226, (2017) (PubMed).

Su, Liu, Wang, Wang, Song, Song: "The electrophilic character of quinones is essential for the suppression of Bach1." in: Toxicology, Vol. 387, pp. 17-26, (2017) (PubMed).

Chen, Li, Fan, Cao, Yao, Xu: "Selenium antagonizes cadmium-induced apoptosis in chicken spleen but not involving Nrf2-regulated antioxidant response." in: Ecotoxicology and environmental safety, Vol. 145, pp. 503-510, (2017) (PubMed).

Kouam, Yuan, Njayou, He, Tsayem, Oladejo, Song, Moundipa, Gao: "Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity." in: Frontiers in pharmacology, Vol. 8, pp. 653, (2017) (PubMed).

Chen, Lin, Liu, Hsu, Lin, Su: "Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154210, (2016) (PubMed).

Lutz, Pace, Arnold: "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." in: Journal of virology, Vol. 90, Issue 13, pp. 6036-48, (2016) (PubMed).

Synonyms and alternative names related to KEAP1

kelch like ECH associated protein 1 (KEAP1), kelch-like ECH-associated protein 1 (Keap1), Kelch-like ECH-associated protein 1 (Keap1), kelch-like ECH-associated protein 1a (keap1a), kelch like ECH associated protein 1 (keap1), kelch like ECH associated protein 1 L homeolog (keap1.L), kelch like ECH associated protein 1 (Keap1), kelch-like ECH-associated protein 1b (keap1b), fb36f11, INrf2, INRF2, Inrf2, keap1, KEAP1, KLHL19, klhl19, mKIAA0132, wu:fb36f11, zgc:171654

Protein level used designations for KEAP1

  • cytosolic inhibitor of Nrf2
  • kelch-like family member 19
  • kelch-like protein 19
  • NRF2 cytosolic inhibitor
  • ring canal protein
  • kelch-like ECH-associated protein 1
  • klhl19
  • LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1
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