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KDM2A 产品

(Lysine (K)-Specific Demethylase 2A (KDM2A))

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

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Featured KDM2A Categories

KDM2A 抗体

High quality antibodies with extensive validation data.

KDM2A 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KDM2A 抗体

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Cat. No. ABIN7193407
Quantity 0.1 mg
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Cat. No. ABIN7244933
Quantity 200 μL
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Application WB, IHC, IHC (p)
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Cat. No. ABIN6736177
Quantity 100 μL
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Recommended KDM2A ELISA试剂盒

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Reactivity Human
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Recommended KDM2A 蛋白

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Cat. No. ABIN1353718
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Latest Publications for our KDM2A Products

Ou, Zhu, Zhao, Li, Tao, Lu, He, Li, Ren, Xu: "HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway." in: Journal of cellular physiology, (2018) (PubMed).

Dhar, Alam, Li, Wagner, Chung, Ahn, Lee: "Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells." in: The Journal of biological chemistry, Vol. 289, Issue 11, pp. 7483-96, (2014) (PubMed).

Wagner, Alam, Dhar, Giri, Li, Wei, Giri, Cascone, Kim, Ye, Multani, Chan, Erez, Saigal, Chung, Lin, Wu, Hung, Heymach, Lee: "KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling." in: The Journal of clinical investigation, Vol. 123, Issue 12, pp. 5231-46, (2013) (PubMed).

Tsukada, Fang, Erdjument-Bromage, Warren, Borchers, Tempst, Zhang: "Histone demethylation by a family of JmjC domain-containing proteins." in: Nature, Vol. 439, Issue 7078, pp. 811-6, (2006) (PubMed).

Andersen, Lam, Leung, Ong, Lyon, Lamond, Mann: "Nucleolar proteome dynamics." in: Nature, Vol. 433, Issue 7021, pp. 77-83, (2005) (PubMed).

Nagase, Ishikawa, Suyama, Kikuno, Hirosawa, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 6, Issue 1, pp. 63-70, (1999) (PubMed).

Synonyms and alternative names related to KDM2A

lysine demethylase 2A (KDM2A), lysine (K)-specific demethylase 2A (Kdm2a), lysine demethylase 2A (Kdm2a), lysine (K)-specific demethylase 2Aa (kdm2aa), 5530401A10Rik, 100043628, AA589516, AW536790, Cxxc8, CXXC8, fb76b11, Fbl7, FBL7, Fbl11, FBL11, FBXL11, Fbxl11, Gm4560, Jhdm1, JHDM1A, Jhdm1a, KDM2A, lalina, LILINA, wu:fb76b11, wu:fj11c04, zgc:158441, zgc:158606

Protein level used designations for KDM2A

  • F-box and leucine-rich repeat protein 11
  • jumonji C domain-containing histone demethylase 1A
  • lysine-specific demethylase 2A
  • F-box protein containing leucine repeats
  • F-box/LRR-repeat protein 11
  • [Histone-H3]-lysine-36 demethylase 1A
  • jmjC domain-containing histone demethylation protein 1A
  • lysine (K)-specific demethylase 2A
  • CXXC-type zinc finger protein 8
  • JmjC domain-containing histone demethylation protein 1B
  • lysine (K)-specific demethylase 2B
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