CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008].
Sengupta, Yang, Hegde, Hegde, Mitra, Pandey, Dutta, Datarwala, Bhakat, Mitra: "Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress." in: DNA repair, Vol. 66-67, pp. 1-10, (2018) (PubMed).
Xiong, Svingen, Sarmento, Smyrk, Dave, Khanna, Lomberk, Urrutia, Faubion: "Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 307, Issue 6, pp. R608-20, (2014) (PubMed).
Cazzalini, Sommatis, Tillhon, Dutto, Bachi, Rapp, Nardo, Scovassi, Necchi, Cardoso, Stivala, Prosperi: "CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis." in: Nucleic acids research, Vol. 42, Issue 13, pp. 8433-48, (2014) (PubMed).