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TUG1 promoted osteosarcoma cell proliferation and suppressed apoptosis by regulating the miR (显示 MLXIP 蛋白)-212-3p/FOXA1 axis.
miR (显示 MLXIP 蛋白)-760 should be considered as a tumor suppressor since it negatively regulates the oncogene (显示 RAB1A 蛋白) protein FOXA1 and regulated TRAIL sensitivity in Non-small cell lung cancer cells.
As a tumor suppressor, FOXA1 targets PIK3R1 directly to inhibit PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) signaling pathway, thus exerting a negative regulatory effect on proliferation, migration, and invasion of HCC (显示 FAM126A 蛋白) in male patients.
miR212 suppresses renal cell carcinoma (显示 MOK 蛋白) (RCC (显示 XRCC1 蛋白)) proliferation and invasion by modulating FOXA1, suggesting that miR212 may have potential as a therapeutic target in RCC (显示 XRCC1 蛋白).
the results of the present study suggested that FOXA1 is a potential oncogene (显示 RAB1A 蛋白) in NSCLC
During the ensuing weeks, the PAX2 (显示 PAX2 蛋白)/FOXA1 boundary progressively extended cranially such that by 21 weeks the entire vaginal epithelium was FOXA1-reactive and PAX2 (显示 PAX2 蛋白)-negative. This observation supports Bulmer's proposal that human vaginal epithelium derives solely from urogenital sinus epithelium
The transcription factor FOXA1 directly bound to the PLOD2 (显示 PLOD2 蛋白) promoter, and turned on PLOD2 (显示 PLOD2 蛋白) transcription. In summary, our findings revealed a regulatory mechanism of NSCLC metastasis through EGFR (显示 EGFR 蛋白)-PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白)-FOXA1-PLOD2 (显示 PLOD2 蛋白) pathway.
maintenance of the cancer cell state is dependent on recruitment of Mediator and Cohesin through FOXA and master transcription factors
overexpression of GATA3 (显示 GATA3 蛋白) and FOXA1 cooperate with PPAR (显示 PPARA 蛋白) activation to drive transdifferentiation of a basal bladder cancer cells to a luminial phenotype.
Results found FOXA1 to be hypermethylated in breast tumors from African American (AA) versus European American (EA) women with ER- cancer, and methylation levels showed strong inverse relationships with both mRNA and protein levels. A significant positive association was identified between parity and FOXA1 methylation in tumors from AA women who did not breastfeed.
we propose a model in which deletion of Foxa1 from STN (显示 EEF1A2 蛋白) neurons evokes a compromised state of the STN (显示 EEF1A2 蛋白), evident by the reduced firing activity of STN (显示 EEF1A2 蛋白) neurons and the loss of a significant fraction of STN (显示 EEF1A2 蛋白) neurons.
this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression
Loss of Interdependent Binding by the FoxO1 (显示 FOXO1 蛋白) and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (显示 INS 蛋白)-sensitive Genes.
FoxA1, FoxA2 (显示 FOXA2 蛋白), and LIPG (显示 LIPG 蛋白) control the uptake of extracellular lipids for breast cancer growth.
genome-wide binding sites of the forkhead/winged helix transcription factor (显示 FOXP2 蛋白) Foxa1, which functions redundantly with Foxa2 (显示 FOXA2 蛋白) to regulate the differentiation of midbrain dopamine neurons, were characterized.
Disruption of Shp (显示 LAMC1 蛋白) in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP (显示 LAMC1 蛋白) inhibits the transcriptional activation of Bhmt (显示 BHMT 蛋白) and cystathionine gamma-lyase (显示 CTH 蛋白) by FOXA1.
ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.
TIP30 (显示 HTATIP2 蛋白) is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.
Mechanistically, JARID1B (显示 KDM5B 蛋白) was required for GATA3 (显示 GATA3 蛋白) recruitment to the Foxa1 promoter to activate Foxa1 expression.
Foxa1 recruited Grg3 to the Nanog (显示 NANOG 蛋白) promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3 (显示 HIST3H3 蛋白).
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
, forkhead box protein A1
, hepatocyte nuclear factor 3-alpha
, transcription factor 3A
, fork head domain
, hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
, hepatocyte nuclear factor 3, alpha
, fork head domain protein 7
, HNF-3 alpha
, HNF3 alpha
, HNF3alpha homolog B
, fork head domain-related protein 7'
, forkhead box protein A1-B
, forkhead protein 2
, hepatocyte nuclear factor 3-alpha homolog B
, forkhead transcription factor FoxA1
, forkhead homolog
, hepatocyte nuclear factor 3 alpha
, forkhead box A1
, hepatocyte nuclear factor 3-alpha-like