-
soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-beta4
-
our data indicate the existence of a positive feedback loop between KLF4 and ITGB4 that promotes GSC self-renewal and gliomagenesis, suggesting that ITGB4 may be a valuable therapeutic target for glioma.
-
Study reports co-segregation of three rare, protein-changing variants in the ITGB4 gene with schizophrenia (SCZ) in 2 families; provides further evidence from case control cohorts that variants in these families may contribute to susceptibility to SCZ and/or bipolar disorder in the wider population; also demonstrates that when these variants are present on the same haplotype there is an increase in cell proliferation.
-
RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter
-
High ITGB4 expression is associated with drug resistance in colorectal cancer.
-
ITGB4 plays a tumorigenic and pro-metastatic role mediated by Slug
-
N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4
-
correlation analysis indicated that the expression of ARRDC3 was negatively correlated with ITGbeta4 in clinical prostate cancer (PCa) tissues and cell lines. Our data revealed that ARRDC3 can serve as a tumor suppressor to inhibit PCa progression and an independent marker to predict the risk of biochemical recurrence and metastasis after radical resection of PCa.
-
ITGB4(+) cancer stem cell (CSC)-enriched mesenchymal cells reside in an intermediate epithelial/mesenchymal phenotypic state.
-
These findings suggest that the integrin beta4-FAK/Src signaling axis may play a crucial role in clonorchiasis-associated cholangiocarcinoma metastasis during tumor progression.
-
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R.
-
MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK at Y397 leading to lung cancer cell migration.
-
Increased integrin alpha6beta4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancers.
-
a significant reduction in the protein distribution of collagen IV (P<0.0001), collagen VII (P<0.001), collagen XVII (P<0.01), integrin beta4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin.
-
alpha6beta4 integrin is a positive regulator of collective cell migration of A549 cells through influence on signal pathways in leader cells.
-
For the in vivo experiment, miR-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR-182-5p may be a key androgen receptor-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.
-
data indicate that the beta4 integrin/FAK complex and subsequent FAK activation are essential regulators during the tumorigenicity of colon cancer
-
This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.
-
Herein, we present a female newborn with lethal Junctional epidermolysis bullosa with pyloric atresia caused by a novel beta4 integrin mutation.
-
analysis of deletions in ITGB4 gene causing epidermolysis bullosa with pyloric atresia [case series]
