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IKZF1 抗体

(IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011].
IKZF1 抗体  (AA 1-265) IKZF1 抗体  (AA 1-265) IKZF1 抗体 (AA 1-265) (ABIN7150361)

IKZF1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

IKZF1 抗体  (C-Term) IKZF1 抗体  (C-Term) IKZF1 抗体 (C-Term) (ABIN654180)

IKZF1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24656 unconjugated

IKZF1 抗体  (C-Term) (PE) IKZF1 抗体  (C-Term) (PE) IKZF1 抗体 (C-Term) (PE) (ABIN2967182)

IKZF1 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal 4E9 PE

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IKZF1 抗体 by 适用

Find IKZF1 抗体 for a variety of species such as anti-Human IKZF1, anti-Mouse IKZF1, anti-Rat IKZF1. The species listed below are among those available. Click on a link to go to the corresponding products.

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IKZF1 抗体 by 抗原表位

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IKZF1 抗体 by 克隆形成能力

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IKZF1 抗体 by 克隆

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IKZF1 抗体 by 标记

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Popular IKZF1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7150361
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN654180
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ICFC
Validations
  • (3)
Cat. No. ABIN2967182
Quantity 100 tests
Datasheet Datasheet
Reactivity Human
Application WB, IF, ChIP
Validations
  • (3)
Cat. No. ABIN7267841
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, FACS, IF, ICC
Validations
  • (4)
Cat. No. ABIN3043860
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application WB
Validations
  • (4)
Cat. No. ABIN2777317
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN948924
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN571070
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, ChIP, ChIP-seq
Validations
  • (1)
  • (2)
Cat. No. ABIN2668828
Quantity 200 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF, IC
Validations
  • (3)
Cat. No. ABIN7306034
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p), EIA
Validations
  • (3)
Cat. No. ABIN952880
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN872958
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN334424
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog, Human
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN2777569
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN901993
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our IKZF1 抗体

Gao, Geng, Song, Lin, Liu, Cai, Cang: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." in: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).

Iempridee, Reusch, Riching, Johannsen, Dovat, Kenney, Mertz: "Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells." in: Journal of virology, Vol. 88, Issue 9, pp. 4811-27, (2014) (PubMed).

Yoshida, Landhuis, Dose, Hazan, Zhang, Naito, Jackson, Wu, Perotti, Kaufmann, Gounari, Morgan, Georgopoulos: "Transcriptional regulation of the Ikzf1 locus." in: Blood, Vol. 122, Issue 18, pp. 3149-59, (2013) (PubMed).

Zarnegar, Rothenberg: "Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer." in: Oncogene, Vol. 31, Issue 43, pp. 4647-54, (2012) (PubMed).

Yeung, Chung, Guess, Bell, Leinwand: "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos." in: Nucleic acids research, Vol. 40, Issue 15, pp. 7303-18, (2012) (PubMed).

Loeper, Asa, Ezzat: "Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation." in: Cancer research, Vol. 68, Issue 10, pp. 3715-23, (2008) (PubMed).

Mullighan, Goorha, Radtke, Miller, Coustan-Smith, Dalton, Girtman, Mathew, Ma, Pounds, Su, Pui, Relling, Evans, Shurtleff, Downing: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." in: Nature, Vol. 446, Issue 7137, pp. 758-64, (2007) (PubMed).

Georgopoulos: "Haematopoietic cell-fate decisions, chromatin regulation and ikaros." in: Nature reviews. Immunology, Vol. 2, Issue 3, pp. 162-74, (2002) (PubMed).

Westman, Mackay, Gell: "Ikaros: a key regulator of haematopoiesis." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 10, pp. 1304-7, (2002) (PubMed).

Nietfeld, Meyerhans: "Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1." in: Immunology letters, Vol. 49, Issue 1-2, pp. 139-41, (1996) (PubMed).

Aliases for IKZF1 抗体

IKAROS family zinc finger 1 (IKZF1) 抗体
IKAROS family zinc finger 1 (Ikzf1) 抗体
IKAROS family zinc finger 1 (Ikaros) (ikzf1) 抗体
IKAROS family zinc finger 1 (ikzf1) 抗体
5832432G11Rik 抗体
hIk-1 抗体
hik-1 抗体
hlk-1 抗体
Hs.54452 抗体
hs.54452 抗体
IK1 抗体
ik1 抗体
IKAROS 抗体
ikaros 抗体
Ikaros 抗体
ikzf1 抗体
LyF-1 抗体
LYF1 抗体
lyf1 抗体
MGC108252 抗体
mKIAA4227 抗体
PRO0758 抗体
pro0758 抗体
RGD1562979 抗体
Zfpn1a1 抗体
ZNFN1A1 抗体
znfn1a1 抗体
Znfn1a1 抗体
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