IKZF1 抗体
(IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011].
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Latest Publications for our IKZF1 抗体
: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." in: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).: "Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells." in: Journal of virology, Vol. 88, Issue 9, pp. 4811-27, (2014) (PubMed).
: "Transcriptional regulation of the Ikzf1 locus." in: Blood, Vol. 122, Issue 18, pp. 3149-59, (2013) (PubMed).
: "Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer." in: Oncogene, Vol. 31, Issue 43, pp. 4647-54, (2012) (PubMed).
: "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos." in: Nucleic acids research, Vol. 40, Issue 15, pp. 7303-18, (2012) (PubMed).
: "Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation." in: Cancer research, Vol. 68, Issue 10, pp. 3715-23, (2008) (PubMed).
: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." in: Nature, Vol. 446, Issue 7137, pp. 758-64, (2007) (PubMed).
: "Haematopoietic cell-fate decisions, chromatin regulation and ikaros." in: Nature reviews. Immunology, Vol. 2, Issue 3, pp. 162-74, (2002) (PubMed).
: "Ikaros: a key regulator of haematopoiesis." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 10, pp. 1304-7, (2002) (PubMed).
: "Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1." in: Immunology letters, Vol. 49, Issue 1-2, pp. 139-41, (1996) (PubMed).
Aliases for IKZF1 抗体
IKAROS family zinc finger 1 (IKZF1) 抗体IKAROS family zinc finger 1 (Ikzf1) 抗体
IKAROS family zinc finger 1 (Ikaros) (ikzf1) 抗体
IKAROS family zinc finger 1 (ikzf1) 抗体
5832432G11Rik 抗体
hIk-1 抗体
hik-1 抗体
hlk-1 抗体
Hs.54452 抗体
hs.54452 抗体
IK1 抗体
ik1 抗体
IKAROS 抗体
ikaros 抗体
Ikaros 抗体
ikzf1 抗体
LyF-1 抗体
LYF1 抗体
lyf1 抗体
MGC108252 抗体
mKIAA4227 抗体
PRO0758 抗体
pro0758 抗体
RGD1562979 抗体
Zfpn1a1 抗体
ZNFN1A1 抗体
znfn1a1 抗体
Znfn1a1 抗体
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