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This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation.
Data indicate that the small proportion of acute heart failure (AHF) patients achieving relaxin-2 concentrations similar to those observed in pregnancy may survive longer.
RL2 level was inversely related to the severity of the atherosclerotic disease; studies with a larger cohort incorporating a consistent study population are warranted to verify results and shed light on the mechanistic background of these processes
High RNL2 expression is associated with Neuroblastoma.
The aim of this study was to investigate plasma levels of relaxin-2 in patients with gestational diabetes mellitus, in comparison to pregnant controls without diabetes.
Second trimester serum concentrations of proRLX2 are not predictive of the development of preeclampsia in pregnancy.
Results indicate that serum relaxin may be a clinically useful indicator for diagnostic and prognostic evaluation in epithelial ovarian cancer (EOC) patients.
Opposite actions of urotensin II and relaxin-2 on cellular expression of fibronectin in renal fibrosis
In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
Relaxin-2 significantly upregulated intracellular processes in human female ACL cells, but no effect was observed in male cells. Relaxin increased MMP (MMP1 and MMP3) and decreased alphaSMA and type I and III collagen expression, which may act to alter the structural integrity of the ACL tissue over time.
Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2) appears to be associated with increased ratio of BCL2/BAX messenger RNA expression; thus, Ang II and/or RLN2 appear to be involved in regulation of apoptosis in prostate epithelium.
Relaxin in the hypothalamic paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway.
serelaxin differentially modulates vascular tone in different vascular beds
a novel fusion transcript comprising the RLN1 and RLN2 genes, was identified.
The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 has been deciphered.
Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.
Relaxin Inhibits High Glucose-Induced Matrix Accumulation in Human Mesangial Cells by Interfering with TGFB1 Production and Mesangial Cells Phenotypic Transition
the correlation between RLN2 and p-AKT or RLN2 and p-ERK1/2 expression was investigated.
Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Effects of RLX on the electrical properties of cardiac stromal cell membrane correlate well with its well-known ability to suppress myofibroblast differentiation, supporting the possibility that RLX may be used for the treatment of cardiac fibrosis.
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants.
, prorelaxin H2
, relaxin, ovarian, of pregnancy
, relaxin 2
, relaxin 3-like protein c
, relaxin 3c
, relaxin family locus X