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抗Mouse (Murine) 抗体:
The aim of this study was to investigate plasma levels of relaxin-2 (显示 RLN1 抗体) in patients with gestational diabetes mellitus, in comparison to pregnant controls without diabetes.
Results indicate that serum relaxin (显示 0 抗体) may be a clinically useful indicator for diagnostic and prognostic evaluation in epithelial ovarian cancer (EOC) patients.
Opposite actions of urotensin II (显示 UTS2 抗体) and relaxin-2 (显示 RLN1 抗体) on cellular expression of fibronectin (显示 FN1 抗体) in renal fibrosis
In a population of acute HF patients, admission relaxin (显示 0 抗体) serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin (显示 0 抗体) as a biomarker in this setting.
Relaxin-2 (显示 RLN1 抗体) significantly upregulated intracellular processes in human female ACL (显示 ACLY 抗体) cells, but no effect was observed in male cells. Relaxin (显示 0 抗体) increased MMP (MMP1 (显示 MMP1 抗体) and MMP3 (显示 MMP3 抗体)) and decreased alphaSMA (显示 ACTA2 抗体) and type I and III collagen expression, which may act to alter the structural integrity of the ACL (显示 ACLY 抗体) tissue over time.
Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2 (显示 RLN1 抗体)) appears to be associated with increased ratio of BCL2 (显示 BCL2 抗体)/BAX (显示 BAX 抗体) messenger RNA expression; thus, Ang II (显示 AGT 抗体) and/or RLN2 (显示 RLN1 抗体) appear to be involved in regulation of apoptosis in prostate epithelium.
Relaxin (显示 0 抗体) in the hypothalamic paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K (显示 PIK3CA 抗体)-Akt (显示 AKT1 抗体) pathway.
a novel fusion transcript comprising the RLN1 (显示 RLN1 抗体) and RLN2 (显示 RLN1 抗体) genes, was identified.
The complex binding mode of the peptide hormone H2 relaxin (显示 0 抗体) to its receptor RXFP1 (显示 RXFP1 抗体) has been deciphered.
Although serum relaxin (显示 0 抗体) level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes (显示 PES1 抗体) planus suggest the hypothesis that relaxin (显示 0 抗体) has a limited and indefinite role in patients with BJHS.
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants.
, prorelaxin H2
, relaxin, ovarian, of pregnancy
, relaxin 2
, relaxin 3-like protein c
, relaxin 3c
, relaxin family locus X