(Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008].
Nagamine, Kudoh, Kawasaki, Minoshima, Asakawa, Ito, Shimizu: "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3." in: Biochemical and biophysical research communications, Vol. 235, Issue 1, pp. 185-90, (1997) (PubMed).
Scott, Chen, Rossier, Lalioti, Antonarakis: "Isolation of a human gene (HES1) with homology to an Escherichia coli and a zebrafish protein that maps to chromosome 21q22.3." in: Human genetics, Vol. 99, Issue 5, pp. 616-23, (1997) (PubMed).
Aliases for HLA-DMA 抗体
RT1 class II, locus DMa (RT1-DMa) 抗体 SLA-DM alpha chain (SLA-DMA) 抗体 major histocompatibility complex, class II, DM alpha (DLA-DMA) 抗体 histocompatibility 2, class II, locus DMa (H2-DMa) 抗体 major histocompatibility complex, class II, DM alpha (HLA-DMA) 抗体 D6S222E 抗体 DMA 抗体 H-2Ma 抗体 H2-Ma 抗体 HLA-DMA 抗体 HLADM 抗体 RING6 抗体 RT1.DMa 抗体 RT1.Ma 抗体