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Suggest that GPC5 is able to suppress the lung adenocarcinoma metastasis by competitively binding to Wnt3a (显示 WNT3A 蛋白) and inactivating the Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling pathway.
GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits tumor growth by suppressing Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling in lung adenocarcinoma.
GPC5 protein expression showed a close correlation with the tumorigenesis and tumor progression of prostate cancer, and that might be applied as a novel biomarker for the prediction of diagnosis and prognosis of prostate cancer.
These results suggest that miR (显示 MLXIP 蛋白)-297 acted as an oncogenic miRNA, partly by targeting GPC5, adenocarcinoma of the lung.
Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.
miR (显示 MLXIP 蛋白)-709 may positively regulate invasion and metastasis of hepatocellular carcinoma through targeting GPC5.
gene variants in IRF5 (显示 IRF5 蛋白), IRF8 (显示 IRF8 蛋白) and GPC5 were not associated with risk of relapse or disease progression in multiple sclerosis
GPC5, a tumor suppressor, is regulated by miR (显示 MLXIP 蛋白)-620 in lung adenocarcinoma.
Variants in the 50-upstream region of GPC5 confer risk of lung cancer in never smokers
These results indicate that GPC5 polymorphisms would be useful genetic indicators for Inflammatory demyelinating diseasess, including neuromyelitis optica and multiple sclerosis .
The findings elucidate the pivotal role of GPC5, identified as a susceptible gene in the genome-wide association study, in hyperglycemia-induced glomerulopathy.
Shh (显示 SHH 蛋白) binds to HSPG (显示 SDC2 蛋白) co-receptors containing a glypican 5 core and 2-O-sulfo-iduronic acid to promote neural precursor proliferation.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
, glypican proteoglycan 5