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These studies provide evidence that a signaling pathway involving agrin, Fgfs and Shh (显示 SHH 蛋白) may be a critical target of ethanol exposure during zebrafish embryogenesis.
Agrin expression and function may be a target of ethanol exposure during embryogenesis.
Agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish.
The presence of agrin at locations with particular importance for the growth and stability of atherosclerotic plaques renders this molecule strategically positioned to influence plaque development and vulnerability
Agrin induces clustering and activation of EphB1 (显示 EPHB1 蛋白) receptors on developing erythroblasts, leading to the activation of alpha5beta1 integrins.
identificaton of agrin, a component of neonatal extracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts
The presence of C-terminal fragment of agrin (CAF (显示 LAMA2 蛋白)) in urine suggests either glomerular filtration or secretion into urine.
Agrin strongly promotes chondrocyte differentiation and cartilage formation in vivo.
Reveal novel roles for APP (显示 APP 蛋白) in regulating neuromuscular synapse formation through hetero-oligomeric interaction with LRP4 (显示 CORIN 蛋白) and agrin and thereby provide new insights into the molecular mechanisms that govern NMJ formation and maintenance.
Agrin is frequently upregulated and important for oncogenic property of hepatocellular carcinoma.
agrin contributes to barrier characteristics of brain endothelium.
NMJs in agrin-deficient mice rapidly disappear after birth. Agrin is essential for postnatal NMJ maintenance, but not for their embryonic formation, and also for the postnatal, but not prenatal, midmuscle localization of postsynaptic specializations.
reviews the evidence that agrin regulates synapse development, plasticity and signaling in the brain and discusses the evidence for the proposed mechanisms
C-terminal agrin fragment levels predict acute kidney injury after acute myocardial infarction.
Agrin promotes oncogenesis through YAP (显示 YAP1 蛋白)-dependent transcription.
Knockdown of agrin and perlecan (显示 HSPG2 蛋白) promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin.
Among 42 hip fractured patients (age 83.7+/-8.6 years, 76.2% women), sarcopenia was diagnosed in 7 individuals (16.7%). Serum C-terminal agrin fragment (CAF (显示 KAT2B 蛋白)) levels were significantly higher in sarcopenic relative to non-sarcopenic patients.
In patients suffering from severe sepsis and septic shock, serum levels of C-terminal agrin fragment were significantly associated with kidney function and the need for renal replacement therapy and were not influenced by severe septic conditions.
MuSK (显示 MUSK 蛋白) myasthenia gravis IgG4 disrupts the interaction of LRP4 (显示 LRP4 蛋白) with MuSK (显示 MUSK 蛋白) but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters
these observations indicate that agrin is another autoantigen in patients with MG and agrin autoantibodies may be pathogenic through inhibition of agrin/LRP4 (显示 LRP4 蛋白)/MuSK (显示 MUSK 蛋白) signaling at the NMJ.
Five new recessive mutations in the gene encoding agrin are identified in patients with congenital myasthenic syndrome.
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found.
, agrin proteoglycan
, heparan sulfate proteoglycan